Sodium tungstate administration ameliorated diabetes-induced electrical and contractile remodeling of rat heart without normalization of hyperglycemia

Biological Trace Element Research
Mustafa AydemirSemir Ozdemir

Abstract

Recently, sodium tungstate was suggested to improve cardiac performance of diabetic rats in perfused hearts based on its insulinomimetic activity. In this study, we aimed to investigate the cellular and molecular mechanisms underlying this beneficial effect of sodium tungstate. Tungstate was administered (100 mg/kg/day) to diabetic and control rats intragastrically for 6 weeks. Blood glucose levels increased, whereas body weight, heart weight and plasma insulin levels decreased significantly in diabetic animals. Interestingly, none of these parameters was changed by tungstate treatment. On the other hand, fractional shortening and accompanying intracellular Ca(2+) [Ca(2+)](i) transients of isolated ventricular myocytes were measured, and sodium tungstate was found to improve the peak shortening and the amplitude of [Ca(2+)](i) transients in diabetic cardiomyocytes. Potassium and L-type Ca(2+) currents were also recorded in isolated ventricular cells. Significant restoration of suppressed I (to) and I (ss) was achieved by tungstate administration. Nevertheless, L-type calcium currents did not change either in untreated or treated diabetic rats. Tissue biochemical parameters including TBARS, protein carbonyl content, xanthine oxi...Continue Reading

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Citations

Feb 20, 2015·Critical Reviews in Toxicology·Ranulfo Lemus, Carmen F Venezia
Feb 15, 2018·Oxidative Medicine and Cellular Longevity·Ning WangYibin Feng
Jan 1, 2019·Journal of Biochemical and Molecular Toxicology·Ghazale CheraghiMir-Jamal Hosseini
Jan 4, 2021·Cardiovascular Toxicology·Feyza AlyuYusuf Ozturk
Feb 2, 2021·World Journal of Diabetes·Nihal OzturkSemir Ozdemir

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