Sodium valproate for the treatment of Tourette׳s syndrome in children: a systematic review and meta-analysis

Psychiatry Research
Chun-Song YangQin Guo

Abstract

The aims are to evaluate the efficacy and safety of sodium valproate for children with Tourette׳s syndrome (TS). We searched PubMed, EMBASE, the Cochrane library, Cochrane Central, CBM, CNKI, VIP, WANG FANG database and relevant reference lists. Five RCTs (N=247) and five case series (N=163) studies were included. Only one RCT (93 patients) evaluated total YGTSS scores and there was significant difference in the reduction of total YGTSS scores between sodium valproate and the control group (3.50±4.59 vs 7.86±7.03, P<0.01). One RCT (30 patients) evaluated motor and vocal tics, and there was significant difference in the reduction of motor and vocal tics scores between sodium valproate and haloperidol (10.45±4.15 vs 14.92±3.01, P<0.01). Meta-analysis of three RCTs (N=124) showed there was no significant difference in the reduction of the number of tics between sodium valproate and the positive control group [Relative Risk (RR)=1.09, 95%CI (0.92, 1.30), P=0.30]. The pooled proportion in five case series studies which used tics symptom improvement self-defined by authors was 80.7% (95% CI: 73.7-86.2, I(2)=0). No fatal side effects were reported. In conclusion, based on the limited evidence, the routine use of sodium valproate for t...Continue Reading

References

May 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·J T WalkupH S Singer
Jul 1, 1989·Journal of the American Academy of Child and Adolescent Psychiatry·J F LeckmanD J Cohen
Jan 11, 2005·Postgraduate Medical Journal·J S SternM M Robertson
Feb 11, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Yasser AwaadSarah Minarik
Jun 15, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Constance L Smith-HicksHarvey S Singer
Feb 13, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Alberto Fernández-JaénBeatriz Calleja-Pérez
May 13, 2009·Pediatric Neurology·Erika F HedderickHarvey S Singer
Sep 4, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·J JankovicL W Brown
Nov 17, 2009·Journal of Psychosomatic Research·Mary May RobertsonAndrea Eugenio Cavanna
Nov 26, 2009·Clinical Neuropharmacology·Sheng-Han Kuo, Joohi Jimenez-Shahed
Dec 8, 2009·BMC Medical Research Methodology·Byron C WallaceThomas A Trikalinos
Sep 21, 2010·Acta neurochirurgica·Marco SassiDomenico Servello
Mar 30, 2011·European Child & Adolescent Psychiatry·Veit RoessnerUNKNOWN ESSTS Guidelines Group
Jun 30, 2011·Frontiers in Integrative Neuroscience·Mauro PortaDomenico Servello
Dec 14, 2011·Therapeutic Advances in Neurological Disorders·Clare M EddyAndrea E Cavanna
Jan 24, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Jeremiah M ScharfYoav Ben-Shlomo
Jun 26, 2012·Neuropharmacology·Veit RoessnerAlexander Münchau
Apr 30, 2013·Handbook of Clinical Neurology·Dominique M Ijff, Albert P Aldenkamp
Aug 22, 2013·BMJ : British Medical Journal·Andrea E Cavanna, Stefano Seri

❮ Previous
Next ❯

Citations

Jan 12, 2016·Neuroscience and Biobehavioral Reviews·Chunsong YangLingli Zhang
Mar 4, 2021·BMJ Case Reports·Ka Loong Kelvin AuIrene A Malaty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.