PMID: 376307Jun 1, 1979Paper

Sodium valproate, serum level and clinical effect in epilepsy: a controlled study

Epilepsia
L GramB Andersen

Abstract

Clinical effects at three different serum levels of sodium valproate (VPA) were compared in a triple-blind, multiple crossover trial comprising 13 epileptic inpatients. Patients were selected regardless of seizure type, and all were in concomitant antiepileptic treatment, which was kept constant throughout the study. A significant relationship between the decrease in number of seizures and increasing VPA serum level was demonstrated. The relationship between VPA dose and serum level was curvilinear. Statistical evaluation of patients by seizure type in relation to clinical effect of VPA was only possible for secondary generalized seizures. Between phenytoin, phenobarbital, and carbamazepine and the different VPA serum levels no interactions could be demonstrated. Recorded side effects were always mild and transient. No obvious correlation between side effects and VPA serum level was established.

References

Jun 1, 1977·Clinical Pharmacology and Therapeutics·U Klotz, K H Antonin
Jun 1, 1977·Epilepsia·K WulffL Gram
Oct 14, 1977·European Journal of Clinical Pharmacology·R GuglerH U Schulz
Feb 1, 1977·Developmental Medicine and Child Neurology·P M JeavonsM C Maheshwari
Nov 15, 1977·Psychopharmacology·N ReisbyJ Christiansen
Feb 28, 1975·European Journal of Clinical Pharmacology·F SchobbenF J Gabreëls
Dec 1, 1975·Developmental Medicine and Child Neurology·D Haigh, W I Forsythe
Nov 1, 1974·Archives of Neurology·H Kutt, J K Penry
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·E van der KleijnF Sjöqvist
Sep 1, 1973·Clinical Pharmacology and Therapeutics·L PalmérM Rawlins
Jan 1, 1966·Scandinavian Journal of Clinical and Laboratory Investigation·P Hansen, E Magid

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Citations

Jan 1, 1982·Journal of Neurology·B LundbergL O Boréus
Jan 1, 1985·European Journal of Clinical Pharmacology·L J LeskoN R Cutler
Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·L Gram
Nov 1, 1985·Indian Journal of Pediatrics·N Buchanan
May 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·F DegelG Weidemann
Jan 1, 1980·Pharmacology & Therapeutics·E H Reynolds
Jan 1, 1995·Pharmacology & Therapeutics·B Rogvi-Hansen, L Gram
Jan 1, 1980·Progress in Neurobiology·J ParnasH Flachs
Jun 1, 1993·Journal of Clinical Pharmacy and Therapeutics·M J Gómez BellverA Domínguez-Gil
Dec 1, 1986·The Japanese Journal of Psychiatry and Neurology·T Kugoh, K Hosokawa
Oct 1, 1982·Epilepsia·L GramH Flachs
Feb 1, 1980·Archives of Disease in Childhood·G W Rylance, T A Moreland
Sep 19, 2006·Drugs·Svein I Johannessen, Elinor Ben-Menachem
Jan 1, 1981·European Journal of Clinical Pharmacology·F HoffmannB C Jancik
Apr 29, 1998·Therapeutic Drug Monitoring·A SundqvistB Lundkvist
Apr 1, 1997·Therapeutic Drug Monitoring·A SundqvistB Lundkvist
Jan 1, 1987·Brain & Development·T IshikawaA Yamaguchi
Aug 12, 2010·Thérapie·Danièle Bentué-FerrerUNKNOWN Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique
Nov 11, 2010·Journal of Clinical Pharmacy and Therapeutics·I B BondarevaK I Bondareva
Jan 1, 1988·British Journal of Clinical Pharmacology·G J MacpheeM J Brodie
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G R GrannemanJ M Machinist
Jan 1, 1985·Biopharmaceutics & Drug Disposition·M BialerF Pachys
Jun 1, 1981·Journal of Veterinary Pharmacology and Therapeutics·W Löscher

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