Abstract
Hepatitis C virus (HCV) is a chronic infection that disproportionately impacts people living with HIV. In the past, HCV therapy was less effective in individuals with HIV co-infection. However, the advent of direct-acting antivirals has revolutionized HCV treatment with high rates of success in patients both with and without HIV. In this paper, we review the evidence supporting the use of ledipasvir and sofosbuvir (LDV/SOF) for the treatment of HCV in patients with HIV co-infection. Articles searchable on MEDLINE/PubMed were reviewed to provide context for use of LDV/SOF in individuals with HCV and HIV co-infection. This treatment is highly effective in achieving HCV cure or sustained virologic response, however further studies need to done to address efficacy of treatment in people with uncontrolled HIV, concerns regarding drug-interactions with antiretroviral therapy, and potential for shorter duration treatment.
References
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C S GrahamM J Koziel
Feb 14, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Norah A TerraultUNKNOWN Solid Organ Transplantation in HIV: Multi-Site Study Investigators
Apr 12, 2014·The New England Journal of Medicine·Kris V KowdleyUNKNOWN ION-3 Investigators
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-2 Investigators
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-1 Investigators
Dec 18, 2014·The Annals of Pharmacotherapy·Michael A SmithRima A Mohammad
Jan 24, 2015·Antiviral Research·Camilla S Graham, Tracy Swan
Feb 24, 2015·JAMA : the Journal of the American Medical Association·Mark S SulkowskiThomas Podsadecki
Feb 24, 2015·JAMA : the Journal of the American Medical Association·Anu OsinusiShyam Kottilil
Mar 20, 2015·Hepatology International·Sarah KattakuzhyShyam Kottilil
Jun 23, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Erik LontokVeronica Miller
Jun 30, 2015·Annals of Internal Medicine·Soumitri BaruaLynn E Taylor
Jul 15, 2015·JAMA : the Journal of the American Medical Association·Anu OsinusiShyam Kottilil
Jul 22, 2015·The New England Journal of Medicine·David L WylesUNKNOWN ALLY-2 Investigators
Jul 22, 2015·The New England Journal of Medicine·Susanna NaggieUNKNOWN ION-4 Investigators
Aug 8, 2015·Current Opinion in HIV and AIDS·Omar El-SherifCaroline Solas
Aug 9, 2015·Gastroenterology·Sophie RenetVincent Algalarrondo
Aug 14, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stacey B TrooskinJay R Kostman
Oct 2, 2015·The Lancet. HIV·Jürgen K RockstrohMark Sulkowski
Oct 24, 2015·Aesthetic Plastic Surgery·Won Joon ChoiHoon Kang
Nov 2, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eleanor M WilsonShyam Kottilil
Nov 5, 2015·The New England Journal of Medicine·Diana M Brainard, John G McHutchison
Nov 5, 2015·The New England Journal of Medicine·Hélène FontaineUNKNOWN Cochin Hepatology and Cardiology Group
Citations
Dec 9, 2016·Hepatology International·Rebecca LeeEleanor Wilson
Nov 1, 2016·Clinical Microbiology Reviews·Eleanor M WilsonShyam Kottilil
Mar 17, 2020·Medicine·Jaspreet BangaShobha Swaminathan
Dec 8, 2017·HIV Medicine·E RosenthalUNKNOWN ANRS HC31 SOFTRIH Study Group
May 31, 2018·Hepatology International·Ameer AbutalebEleanor Wilson