Sofosbuvir Plus Daclatasvir in Treatment of Chronic Hepatitis C Genotype 4 Infection in a Cohort of Egyptian Patients: An Experiment the Size of Egyptian Village

International Journal of Hepatology
Ossama A AhmedSherief Abd-Elsalam

Abstract

As indicated by the World Health Organization (WHO), Egypt is positioned as the country with the world's highest prevalence of Hepatitis C virus (HCV). HCV is transmitted through unexamined blood transfusions, different employments of syringes, and poor cleansing, as per the WHO. Our study aimed at screening and management of chronic hepatitis C genotype 4 infected patients in Bardeen village, Sharkeya Governorate, Egypt, with Sofosbuvir plus Daclatasvir, as well as estimating the safety and efficacy of that regimen. Screening of adult patients in Bardeen village was done from March 2016 till November 2016 using hepatitis C virus antibodies by third-generation ELISA testing. Positive results were confirmed by PCR. Patients eligible for treatment received Sofosbuvir 400 mg and Daclatasvir 60 mg daily for 12 weeks and were assessed for sustained virologic response at 12 weeks following the end of treatment (SVR 12). Out of 2047 subjects screened for hepatitis C virus, 249 (12.2%) showed positive results. 221 out of those 249 subjects (88.7%) had detectable RNA by PCR. Treatment of eligible patients (183 patients) with Sofosbuvir plus Daclatasvir for 12 weeks resulted in 96% achievement of sustained virologic response at week 12. ...Continue Reading

References

Aug 3, 2014·Journal of Hepatology·Erin GowerHomie Razavi
Jan 21, 2016·Alimentary Pharmacology & Therapeutics·D Banerjee, K R Reddy
Jan 26, 2016·World Journal of Hepatology·Gaetano BertinoMichele Malaguarnera
Oct 19, 2016·BMJ Open Gastroenterology·Emma Hathorn, Ahmed M Elsharkawy
May 11, 2018·Journal of Clinical and Experimental Hepatology·Rajiv MehtaViral Parekh

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Citations

May 23, 2019·Clinical Pharmacokinetics·Elise J SmoldersDavid M Burger
Jan 1, 2020·Journal of Clinical Pharmacy and Therapeutics·Abdel-Hameed Ibrahim Mohammed EbidRadwa Samir Hagag
Aug 27, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Hanan SolimanSherief Abd-Elsalam
May 31, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Amany Mohamed Abo-EleneinSherief Abd-Elsalam
May 14, 2020·Expert Review of Anti-infective Therapy·Omkolsoum AlhaddadMaha Elsabaawy
Jan 22, 2019·Infectious Disorders Drug Targets·Amal Ahmed MohamedSherief Abd-Elsalam
Jul 28, 2020·International Journal of Clinical Pharmacy·Abdel-Hameed Ibrahim Mohamed EbidRadwa Samir Hagag
Aug 16, 2019·World Journal of Gastroenterology : WJG·Massimo Giuseppe ColomboSanjay Hadigal
Aug 11, 2020·Advances in Virology·Yousry Esam-Eldin Abo-AmerSherief Abd-Elsalam
Sep 10, 2020·Virusdisease·Masoud KeikhaMohsen Karbalaei
Oct 6, 2019·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mortada El-Shabrawi, Fetouh Hassanin
May 12, 2020·Gastroenterology Clinics of North America·Ashley N Tran, Joseph K Lim
May 7, 2019·Infectious Disorders Drug Targets·Eman Mohammed HelalDina Hazem Ziada
Apr 3, 2021·Journal of Viral Hepatitis·Blessing DzingiraiNyashadzaishe Mafirakureva
May 22, 2021·Immunological Investigations·Ann Abd-Almonem FaridHanan M Bedair
May 16, 2021·Microbiology and Immunology·Ashraf ElbahrawyHussein Hassan Aly

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Methods Mentioned

BETA
ELISA
pregnancy test
PCR

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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