Sofosbuvir Use in the Setting of End-stage Renal Disease: A Single Center Experience

Journal of Clinical and Translational Hepatology
Avin AggarwalAijaz Ahmed

Abstract

Background and Aims: Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) who are dialysis-dependent form a unique group, in which safety, tolerability and efficacy of sofosbuvir (SOF)-based direct-acting antivirals (DAAs) need further evaluation. Methods: We performed a retrospective analysis of 14 patients with CHC and ESRD on dialysis who received 15 courses of SOF-based therapy. We evaluated dose escalation to standard-dose SOF in this proof-of-principle experience. Results: Sustained virological response (defined as undetectable viral load at 12 weeks, SVR-12) was achieved in 13 out of the 15 (86.7%) treatment courses. Seven (46.6%) patients received reduced half dose as conservative proof-of-principal to mitigate potential toxicity. In 13 out of 15 treatment courses, patients completed the designated treatment duration. One patient was treated twice and developed SVR-12 with the retreatment. One patient was lost to follow-up and counted as a non-responder. Premature discontinuations were not due to DAA-related adverse effects. There were no reports of severe adverse effects or drug interactions. Conclusion: We treated CHC patients with ESRD using dose escalation to standard-dose SOF in this proof-of-...Continue Reading

References

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Citations

Oct 12, 2019·Journal of Viral Hepatitis·Kimberly E DanielSyed Rizvi
Jan 30, 2020·Journal of Gastroenterology and Hepatology·Hossein PoustchiReza Malekzadeh
Aug 17, 2018·Infectious Disorders Drug Targets·Deepti Chopra, Bharti Bhandari
Feb 3, 2018·World Journal of Gastroenterology : WJG·Chiranjeevi GadiparthiAijaz Ahmed
Feb 6, 2020·Journal of Nephrology·Gaetano AlfanoGianni Cappelli
Oct 6, 2019·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mortada El-Shabrawi, Fetouh Hassanin

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