Soft and MRI Compatible Neural Electrodes from Carbon Nanotube Fibers

Nano Letters
Linlin LuXiaojie Duan

Abstract

Soft and magnetic resonance imaging (MRI) compatible neural electrodes enable stable chronic electrophysiological measurements and anatomical or functional MRI studies of the entire brain without electrode interference with MRI images. These properties are important for many studies, ranging from a fundamental neurophysiological study of functional MRI signals to a chronic neuromodulatory effect investigation of therapeutic deep brain stimulation. Here we develop soft and MRI compatible neural electrodes using carbon nanotube (CNT) fibers with a diameter from 20 μm down to 5 μm. The CNT fiber electrodes demonstrate excellent interfacial electrochemical properties and greatly reduced MRI artifacts than PtIr electrodes under a 7.0 T MRI scanner. With a shuttle-assisted implantation strategy, we show that the soft CNT fiber electrodes can precisely target specific brain regions and record high-quality single-unit neural signals. Significantly, they are capable of continuously detecting and isolating single neuronal units from rats for up to 4-5 months without electrode repositioning, with greatly reduced brain inflammatory responses as compared to their stiff metal counterparts. In addition, we show that due to their high tensile ...Continue Reading

References

Nov 1, 1993·Journal of Biomedical Materials Research·S SchmidtR Normann
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Avshalom Shenhav, Haim Azhari
Jun 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hansjörg GrafFritz Schick
Oct 4, 2005·Journal of Neuroscience Methods·Vadim S PolikovWilliam M Reichert
Jun 24, 2006·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Justin C SanchezPaul R Carney
Jun 1, 2007·Journal of the American Chemical Society·Hong-Zhang GengYoung Hee Lee
Apr 24, 2008·Annual Review of Biomedical Engineering·Stuart F Cogan
Jun 3, 2009·Nature·Evgueniy V Lubenov, Athanassios G Siapas
Aug 25, 2009·Journal of Neural Engineering·George C McConnellRavi V Bellamkonda
Aug 6, 2010·Brain : a Journal of Neurology·Matt SteadGreg A Worrell
Oct 14, 2010·Small·Jingna ZhaoQingwen Li
Nov 26, 2010·Nature Neuroscience·Qi WangGarrett B Stanley
Feb 12, 2011·Journal of Neurotrauma·Nadia GosselinAlain Ptito
Jul 22, 2011·Journal of Neural Engineering·Cynthia A ChestekKrishna V Shenoy
Sep 20, 2011·Frontiers in Neuroscience·Jit MuthuswamyArati Sridharan
Sep 27, 2012·Journal of Neural Engineering·Abhishek PrasadJustin C Sanchez
Nov 13, 2012·Nature Materials·Takashi D Yoshida KozaiDaryl R Kipke
Nov 21, 2012·Nature Reviews. Neuroscience·William J Tyler
Feb 23, 2013·Journal of Neural Engineering·C Q JiangL M Li
Jul 19, 2013·Journal of Neural Engineering·Grigori GuitchountsTimothy J Gardner
Mar 29, 2014·Advanced Materials·Pouria FattahiMohammad Reza Abidian
Feb 20, 2015·Journal of Neurophysiology·Cory A MasseyGeorge B Richerson
Jun 25, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daniil P AksenovAlice M Wyrwicz
Jan 19, 2016·Cell Reports·Clarissa J WhitmireGarrett B Stanley
Aug 30, 2016·Nature Methods·Tian-Ming FuCharles M Lieber
Feb 10, 2018·Current Opinion in Biomedical Engineering·Kevin WoeppelXinyan Tracy Cui

❮ Previous
Next ❯

Citations

Jan 25, 2020·Advanced Healthcare Materials·Manping Jia, Marco Rolandi
May 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chengqiang TangHuisheng Peng
Jul 17, 2020·Chemical Society Reviews·Yin FangBozhi Tian
Jun 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mingchao ZhangYingying Zhang
Jan 23, 2020·Materials·Patrycja TaborowskaAgnieszka Lekawa-Raus
Aug 5, 2020·Nature Nanotechnology·Wei YanFabien Sorin
Dec 15, 2020·Biomaterials·Yihang ChenGuosong Hong
Jan 15, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Steven GibneyFrankie J Rawson
Oct 4, 2020·Biosensors & Bioelectronics·Shuangjie LiuDong Ming
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Weiyang YangWen Li
Apr 30, 2021·Frontiers in Neuroscience·Maryam HejaziDavid J Garrett
May 21, 2021·Advanced Materials·Yo Han ChoJang-Ung Park
Aug 18, 2021·Journal of Neural Engineering·Mamta DeviSwati Sharma
Sep 4, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Allison D PostMehdi Razavi
Nov 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Boyu XuXiao-Dong Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.