Soft Electrochemical Probes for Mapping the Distribution of Biomarkers and Injected Nanomaterials in Animal and Human Tissues

Angewandte Chemie
Tzu-En LinHubert H Girault

Abstract

Monitoring biomarkers and injected theranostic nanomaterials in tissues and organs plays a pivotal role in numerous medical applications ranging from cancer diagnostics to drug delivery. Scanning electrochemical microscopy has been demonstrated as a powerful tool to create highly resolved maps of the distributions of relevant biomolecules in cells and tissues without suffering from the optical interferences of conventional microscopy. We demonstrate for the first time the application of soft microelectrodes brushing in contact mode over large and thick tissues as well as organs that were immersed in an electrolyte solution. Amperometric currents were recorded based on the local flux of redox-active species locally and specifically generated by the biomarkers and nanomaterials to create maps of the biodistribution of graphene oxide nanoribbons in mouse livers, prognostic protein biomarkers in human melanoma and redox-active proteins in mouse heart.

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Citations

Jun 15, 2018·Chemical Science·Tzu-En LinAndreas Lesch
Apr 16, 2020·Advanced Biosystems·Kosuke InoHitoshi Shiku
Sep 19, 2019·Analytical Chemistry·Sorour DarvishiAndreas Lesch
Aug 29, 2018·Analytical Chemistry·Glen D O'NeilDaniel V Esposito
Oct 20, 2018·Journal of the American Chemical Society·Silvia VociNeso Sojic

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