Soft Nanotubes Derivatized with Short PEG Chains for Thermally Controllable Extraction and Separation of Peptides

ACS Omega
Naohiro KametaJiuchao Dong

Abstract

By means of a two-step self-assembly process involving three components, including short poly(ethylene glycol) (PEG) chains, we produced two different types of molecular monolayer nanotubes: nanotubes densely functionalized with PEG chains on the outer surface and nanotubes densely functionalized with PEG chains in the nanochannel. Turbidity measurements and fluorescence spectroscopy with an environmentally responsive probe suggested that the PEG chains underwent dehydration when the nanotubes were heated above 44-57 °C and rehydration when they were cooled back to 25 °C. Dehydration of the exterior or interior PEG chains rendered them hydrophobic and thus able to effectively extract hydrophobic amino acids from the bulk solution. Rehydration of the PEG chains restored their hydrophilicity, thus allowing the extracted amino acids to be squeezed out into the bulk solutions. The nanotubes with exterior PEG chains exhibited selectivity for all of the hydrophobic amino acids, whereas the interior PEG chains were selective for hydrophobic amino acids with an aliphatic side chain over hydrophobic amino acids with an aromatic side chain. The higher selectivity of the latter system is attributable that the extraction and back-extractio...Continue Reading

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Citations

Jul 19, 2018·Small·Naohiro Kameta, Haruhisa Akiyama
May 19, 2021·Journal of the American Chemical Society·Michael J StraussWilliam R Dichtel
Feb 6, 2020·Chemical Reviews·Toshimi ShimizuNaohiro Kameta

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Methods Mentioned

BETA
circular dichroism
fluorescence resonance
dynamic light scattering
fluorescence spectroscopy
fluorescence
membrane filtration
X-ray

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