The degree to which adaptation in recent human evolution shapes genetic variation remains controversial. This is in part due to the limited evidence in humans for classic "hard selective sweeps", wherein a novel beneficial mutation rapidly sweeps through a population to fixation. However, positive selection may often proceed via "soft sweeps" acting on mutations already present within a population. Here, we examine recent positive selection across six human populations using a powerful machine learning approach that is sensitive to both hard and soft sweeps. We found evidence that soft sweeps are widespread and account for the vast majority of recent human adaptation. Surprisingly, our results also suggest that linked positive selection affects patterns of variation across much of the genome, and may increase the frequencies of deleterious mutations. Our results also reveal insights into the role of sexual selection, cancer risk, and central nervous system development in recent human evolution.
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria
Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation
The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations
Hitchhiking effects of recurrent beneficial amino acid substitutions in the Drosophila melanogaster genome
Genomewide spatial correspondence between nonsynonymous divergence and neutral polymorphism reveals extensive adaptation in Drosophila
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
Searching for footprints of positive selection in whole-genome SNP data from nonequilibrium populations
A new test for detecting recent positive selection that is free from the confounding impacts of demography
Distinguishing positive selection from neutral evolution: boosting the performance of summary statistics
Pervasive adaptive protein evolution apparent in diversity patterns around amino acid substitutions in Drosophila simulans
Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1
Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome
A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum
Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity
1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans
Differential strengths of positive selection revealed by hitchhiking effects at small physical scales in Drosophila melanogaster
A C++ template library for efficient forward-time population genetic simulation of large populations
OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders
Soft shoulders ahead: spurious signatures of soft and partial selective sweeps result from linked hard sweeps
Peto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer
dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs
Inferring Selective Constraint from Population Genomic Data Suggests Recent Regulatory Turnover in the Human Brain
Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs
Differential Gene Expression in the Human Brain Is Associated with Conserved, but Not Accelerated, Noncoding Sequences
Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia
Faster-X evolution of gene expression is driven by recessive adaptive cis-regulatory variation in Drosophila
Selection, Linkage, and Population Structure Interact To Shape Genetic Variation Among Threespine Stickleback Genomes
Polygenic selection drives the evolution of convergent transcriptomic landscapes across continents within a Nearctic sister species complex
Detection and Classification of Hard and Soft Sweeps from Unphased Genotypes by Multilocus Genotype Identity
On the unfounded enthusiasm for soft selective sweeps II: Examining recent evidence from humans, flies, and viruses
Complex Haplotypes of GSTM1 Gene Deletions Harbor Signatures of a Selective Sweep in East Asian Populations
Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation
Bioinformatic Detection of Positive Selection Pressure in Plant Pathogens: The Neutral Theory of Molecular Sequence Evolution in Action
Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans
Selection plays the hand it was dealt: evidence that human adaptation commonly targets standing genetic variation
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Synthetic Genetic Array Analysis
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.
Cell Atlas of the Human Eye
Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.
Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.