Soft-tissue and bone sarcoma histopathology peer review: the frequency of disagreement in diagnosis and the need for second pathology opinions. The Southeastern Cancer Study Group experience

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
C A PresantY S Fu

Abstract

Histopathologic peer review of specimens from 216 consecutive patients with soft-tissue or bone sarcomas on Southeastern Cancer Study Group protocols was performed by a panel of three pathologists. Subtype of sarcoma, degree of confidence in diagnosis, and grade were compared with agreement or disagreement in pathologic opinion from the primary member institution v the pathology review panel. The most common soft-tissue sarcoma was leiomyosarcoma, followed by malignant fibrous histiocytoma, fibrosarcoma, liposarcoma, malignant schwannoma, and rhabdomyosarcoma. There was total agreement between the primary pathologist and reviewer in 66% of cases. However, 12 cases (6%) were considered on review to not be sarcomas. In 27% of cases the subtype of sarcoma was felt to be incorrect by reviewers. Discordant diagnoses were more common when the confidence of the pathologist was less and when the tumor was of higher grade. There was no improvement in frequency of agreement in the second half of the study, despite educational workshops. We conclude that histologic peer review is important in sarcoma studies and is essential in many patients with presumed sarcomas.

Citations

May 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B A AgnarssonJ Hrafnkelsson
Nov 21, 1997·Annals of Surgical Oncology·S SingerC Fletcher
Jun 3, 1999·The Australian and New Zealand Journal of Surgery·G B MannM F Brennan
Dec 22, 1999·Journal of Clinical Pathology·J F Graadt van RoggenP C Hogendoorn
Oct 6, 2007·Journal of Surgical Oncology·Marcus LehnhardtHans Ulrich Steinau
Jun 27, 2008·Journal of Pediatric Orthopedics·Hendrik van den BergPancras Hogendoorn
Oct 23, 2014·Journal of Surgical Oncology·David M Thomas, Mandy L Ballinger
Oct 8, 2017·Circulation. Cardiovascular Genetics·Aisha FurqanUNKNOWN SHaRe Consortium
Jul 14, 1999·Seminars in Surgical Oncology·S Singer
Apr 16, 2002·Clinical Orthopaedics and Related Research·Albert J AboulafiaJames Blum
Jun 26, 2013·AJR. American Journal of Roentgenology·Rajan RakhejaMarc Hickeson
Dec 9, 2014·Journal of Surgical Oncology·Marcus C B Tan, Sam S Yoon
Feb 3, 2016·Cancer Biomarkers : Section a of Disease Markers·Yanyan LiWeiqiang Yao
Jun 28, 2017·Journal of Magnetic Resonance Imaging : JMRI·Valentina D A CorinoLuca T Mainardi
Jan 1, 1989·Cancer Investigation·P Dal Cin, A A Sandberg
Feb 14, 1991·The New England Journal of Medicine·J A FletcherJ M Corson
Jul 5, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Bruce K WobeserAndrew L Allen
Dec 25, 2007·Journal of Pediatric Orthopedics·Hendrik van den BergPancras Hogendoorn
Jan 16, 2013·Skeletal Radiology·Robert A LefkowitzDavid M Panicek
Oct 14, 2011·Japanese Journal of Clinical Oncology·Ta-I WangTain-Hsiung Chen
Jul 6, 2020·Journal of Medical Case Reports·Elise LuponThomas Meresse
Sep 10, 2003·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Isabelle HosteinAlain Aurias

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