PMID: 9555993Apr 29, 1998Paper

Soft-tissue complications of intra-arterial chemotherapy for extremity sarcomas

Annals of Plastic Surgery
H P BezwadaA J Weiss

Abstract

High-grade sarcomas have a high rate of local recurrence as well as distant metastases. This has led to the development of intra-arterial chemotherapy (IAC) as part of a multimodal approach to control local disease and/or reduce the extent of surgical resection. Intra-arterial catheters are positioned by an interventional radiologist into the feeding vessels of the tumor. Adriamycin and 5-fluorodeoxyuridine are infused intra-arterially. Cisplatinum, with or without granulocyte colony stimulating factor, is given systemically. Patients usually experience acute self-limited soft-tissue inflammation in the treated area. In our experience of 118 patients, 3 patients experienced soft-tissue necrosis that required excision and reconstruction. The first was treated for synovial sarcoma of a metatarsal. After IAC with Adriamycin, she sloughed the skin, subcutaneous tissue, and some of the posterior compartment musculature of her calf. This tissue was debrided. A gastrocnemius flap and skin graft were used for coverage. She is free of disease and ambulatory. The second patient was treated with IAC Adriamycin for a radial head chondrosarcoma. She developed soft-tissue slough, which became infected with Pseudomonas. She required extensive...Continue Reading

Citations

Jun 10, 2003·Annals of Surgical Oncology·Ross M WilkinsAnne B Camozzi
Jul 24, 2008·Annals of Surgical Oncology·Marc D MoncrieffJohn F Thompson
Jan 24, 2007·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Jayme S Looper
Aug 18, 2005·Journal of Vascular and Interventional Radiology : JVIR·John W CullenCynthia M Kelly
Aug 16, 2015·Integrative Cancer Therapies·Gregory T LevinRobert U Newton

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