Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
U M HollensteinM Müller

Abstract

To investigate whether weight adjusted ciprofloxacin dosing results in comparable target site concentrations in obese and lean subjects. Comparative study in two populations. Twelve obese subjects (mean weight 122+/-22.6 kg, 28-52 y, male&ratio;female ratio 4&ratio;8) and 12 age- and sex-matched lean controls (mean weight 59+/-8.6 kg). Sampling of interstitial space fluid by means of calibrated in vivo microdialysis after a weight-adjusted intravenous bolus dose of 2.85 mg/kg ciprofloxacin. Analysis of drug concentration by high pressure liquid chromatography. We found significantly higher peak and trough levels of ciprofloxacin in plasma for obese subjects (9.97+/-5.64 and 0.44+/-0.10 microg/ml vs 2.59+/-1.06 and 0.19+/-0.09 microg/ml in lean subjects, P<0.05), while concentration-time curves of interstitial fluid of muscle and subcutaneous fat did not differ between the groups. Tissue penetration, expressed as AUC(tissue)/AUC(plasma) ratio was significantly lower in obese subjects (0.45+/-0.27 vs 0.82+/-0.36, P<0.01). We conclude that the penetration process into the interstitial space fluid is impaired in obese subjects. Therefore antibiotic doses need not be adjusted for an increase in fat/water ratio. Weight-adjusted dosin...Continue Reading

References

Oct 1, 1991·Journal of Internal Medicine·U Ungerstedt
Apr 1, 1982·Antimicrobial Agents and Chemotherapy·R A BlouinW O Griffen
Feb 1, 1995·Antimicrobial Agents and Chemotherapy·A M TraynorJ S Bertino
Oct 1, 1994·Therapeutic Drug Monitoring·M P DucharmeD J Edwards
Oct 1, 1993·Clinical Pharmacology and Therapeutics·S AllardM LeBel
May 1, 1993·The Pediatric Infectious Disease Journal·M N Dudley
Dec 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·G J KrolT Benham
Dec 1, 1996·Antimicrobial Agents and Chemotherapy·M MüllerH G Eichler
Jul 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R WurtzK Rodvold
Jun 19, 1998·Therapeutic Drug Monitoring·S R PenzakS L Hickerson
Dec 22, 1998·European Journal of Clinical Pharmacology·L A BauerJ S Lill

❮ Previous
Next ❯

Citations

Oct 1, 2011·International Journal of Clinical Pharmacy·Claudia LangebrakeAxel R Zander
Jun 5, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Gerald HuschakUdo X Kaisers
Dec 8, 2000·Advanced Drug Delivery Reviews·M Müller
May 15, 2003·Nuclear Medicine and Biology·Oliver LangerMarkus Müller
May 2, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R Huttunen, J Syrjänen
Apr 9, 2011·The Journal of Antimicrobial Chemotherapy·Sonia LuqueAntoni Ferrer
Jul 7, 2011·The Journal of Antimicrobial Chemotherapy·Martin G KeesThomas Horbach
Jun 6, 2007·Antimicrobial Agents and Chemotherapy·Manjunath P PaiRenee-Claude Mercier
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Markus MüllerHartmut Derendorf
Nov 12, 2013·The Journal of Antimicrobial Chemotherapy·Margreke J E BrillCatherijne A J Knibbe
May 27, 2014·The American Journal of Emergency Medicine·Duk Hee LeeYoung Jin Cheon
Jun 21, 2015·Expert Review of Anti-infective Therapy·Young R LeeRonald G Hall
Apr 15, 2015·Gynecologic Oncology·Neil S Horowitz, Alexi A Wright
Dec 16, 2011·The American Journal of Emergency Medicine·Jada L RoeMichael E Mullins
Aug 25, 2009·Clinics in Chest Medicine·Shyoko Honiden, John R McArdle
Jul 28, 2007·Pharmacotherapy·Manjunath P Pai, David T Bearden
Jan 25, 2008·Alcoholism, Clinical and Experimental Research·Eric A EnglemanWilliam J McBride
Apr 1, 2015·Clinical Obesity·C E TuckerN H Nguyen
Mar 5, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Eduardo Asín-PrietoArantxazu Isla
May 10, 2017·Expert Review of Anti-infective Therapy·Ronald G HallCarlos A Alvarez
May 9, 2014·Expert Review of Anti-infective Therapy·Kenna D Payne, Ronald G Hall
Apr 5, 2013·Clinical Microbiology Reviews·Daniel GonzalezHartmut Derendorf
Feb 13, 2019·Current Hypertension Reports·Jordana B Cohen, Kishore M Gadde
Sep 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Justine M RussellBrandon D Nornhold
Jan 14, 2010·Clinical Pharmacokinetics·Michael J HanleyDavid J Greenblatt
Aug 27, 2005·Clinical Pharmacokinetics·Christian Joukhadar, Markus Müller
Apr 14, 2006·Chemotherapy·Lucyna KoniecznaHenryk Lamparczyk
Jun 16, 2010·Expert Review of Pharmacoeconomics & Outcomes Research·Teena ChopraKeith S Kaye
May 17, 2011·Therapeutic Drug Monitoring·Seth J SternGideon Koren
Oct 9, 2012·Current Opinion in Infectious Diseases·Brett Janson, Karin Thursky
Sep 5, 2015·Current Opinion in Otolaryngology & Head and Neck Surgery·Shawn M StevensTed A Meyer
May 30, 2020·Obstetrical & Gynecological Survey·S Allison StaleyLeslie H Clark
Jun 3, 2011·Clinical Pharmacology and Therapeutics·R JainC G Sahajwalla
Feb 13, 2018·Expert Opinion on Drug Metabolism & Toxicology·Cornelis SmitCatherijne A J Knibbe
Apr 28, 2019·International Journal of Molecular Sciences·Steffi GoffartJaakko L O Pohjoismäki
Aug 26, 2017·Current Cardiology Reports·Jordana B Cohen
Aug 14, 2020·The Journal of Antimicrobial Chemotherapy·Cornelis SmitCatherijne A J Knibbe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.