Soft-tissue sarcoma of the thigh: surgical margin influences local recurrence but not survival in 152 patients

Acta Orthopaedica Scandinavica
S VraaO M Jensen

Abstract

Between 1979 and 1998, 152 patients with a soft-tissue sarcoma arising in the thigh were surgically treated in the Sarcoma Center in Aarhus, Denmark. We studied clinicopathologic factors prognostic for local recurrence and survival. 27 patients (18%) had a low-grade tumor, 26 (17%) an intermediate-grade and 99 (65%) a high-grade tumor. 27 patients (18%) were amputated and 125 (82%) had a local resection. 21 (14%) underwent a marginal resection, 82 (54%) a wide resection and 49 (32%) a compartmental resection. 32 patients were also given radiotherapy, 11 of these had a marginal resection. The 5-year local recurrence-free rate was 91%. Multivariate analysis selected marginal resection and histological high grade as unfavorable prognostic factors for local recurrence. The 5-year survival rate was 68%. High age and histological high grade were unfavorable prognostic factors for survival in a multivariate analysis. Surgical margin influenced local recurrence, but not the overall survival.

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Citations

Jun 9, 2005·Hematology/oncology Clinics of North America·Michelle Scurr, Ian Judson
Oct 29, 2010·Sarcoma·Brendan PrendergastDaniel J Indelicato
Mar 1, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D A MüllerR Capanna
Oct 2, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideshi SugiuraKenji Yamada
Jan 19, 2016·Journal of Surgical Oncology·Heidi Buvarp DyropJohnny Keller
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May 28, 2019·Current Treatment Options in Oncology·Makoto EndoYoshihiro Matsumoto
Apr 9, 2019·International Journal of Surgical Oncology·Tine Rytter SoerensenThomas Baad-Hansen
Feb 7, 2020·Current Treatment Options in Oncology·Elyse J BrinkmannMatthew T Houdek
Feb 23, 2019·Clinical Orthopaedics and Related Research·Hideshi SugiuraYoshihiro Nishida

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