Soft yet Sharp Interfaces in a Vertex Model of Confluent Tissue

Physical Review Letters
Daniel M SussmanM Lisa Manning

Abstract

How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the ability of cells to independently regulate adhesivity and tension, together with neighbor-based interaction rules, lets them support strikingly unusual interfaces. In particular, we show that mechanical- and fluctuation-based measurements of the effective surface tension of a cellular aggregate yield different results, leading to mechanically soft interfaces that are nevertheless extremely sharp.

References

Apr 4, 1994·Physical Review Letters·R A FotyM S Steinberg
Sep 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·M S STEINBERG
Dec 13, 2006·Physical Review Letters·Erik BitzekPeter Gumbsch
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lars HufnagelBoris I Shraiman
Jul 13, 2007·Current Opinion in Genetics & Development·Malcolm S Steinberg
Dec 18, 2007·Current Biology : CB·Reza FarhadifarFrank Jülicher
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·M BalleriniV Zdravkovic
Jun 24, 2009·Nature Reviews. Molecular Cell Biology·Peter Friedl, Darren Gilmour
Aug 8, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A Hocevar, P Ziherl
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Philippe MarmottantHélène Delanoë-Ayari
Nov 3, 2009·Current Biology : CB·Katharina P LandsbergChristian Dahmann
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·M Lisa ManningEva-Maria Schoetz
Dec 18, 2010·Nature Reviews. Genetics·Christian DahmannMichael Brand
Jan 15, 2011·Physical Review Letters·Francesco Ginelli, Hugues Chaté
Mar 26, 2011·Cellular and Molecular Life Sciences : CMLS·Bruno MonierBénédicte Sanson
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·James E Herbert-ReadAshley J W Ward
Dec 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Silke HenkesM Cristina Marchetti
Aug 28, 2012·Science·Jean-Léon MaîtreCarl-Philipp Heisenberg
Sep 26, 2012·Physical Review Letters·Anton PeshkovFrancesco Ginelli
Sep 26, 2012·Physical Review Letters·Aaron F MertzEric R Dufresne
Oct 15, 2013·Progress in Biophysics and Molecular Biology·Alexander G FletcherDavid J Gavaghan
Mar 22, 2014·Soft Matter·Dapeng BiM Lisa Manning
Jun 5, 2014·Biophysical Journal·Alexander G FletcherStanislav Y Shvartsman
Sep 16, 2015·Physical Review Letters·Julian BialkéThomas Speck
Sep 1, 2014·Nature Physics·Agustí BruguésXavier Trepat
Jan 14, 2017·The European Physical Journal. E, Soft Matter·Meryl A SpencerDavid K Lubensky
Jul 1, 2017·PLoS Computational Biology·Daniel L BartonRastko Sknepnek
Apr 1, 2016·Physical Review. X·Dapeng BiM Lisa Manning

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Citations

Apr 19, 2018·Soft Matter·Daniel M Sussman, Matthias Merkel
Mar 21, 2020·Soft Matter·Preeti SahuJ M Schwarz
Sep 7, 2019·Physical Review Letters·Xinzhi LiDapeng Bi
Nov 26, 2019·Physical Review Letters·Marc Durand, Julien Heu
Dec 24, 2018·Physical Review Letters·John J Williamson, Guillaume Salbreux
Jan 17, 2021·Developmental Cell·Pierre-François LenneVirgile Viasnoff
Jul 1, 2020·Seminars in Cell & Developmental Biology·François Fagotto
Jul 28, 2020·Seminars in Cell & Developmental Biology·François Fagotto
Jun 8, 2021·PLoS Computational Biology·Gonca Erdemci-Tandogan, M Lisa Manning
Nov 2, 2020·Biophysical Journal·Diogo E P PintoNuno A M Araújo
Jan 1, 2019·ACS Biomaterials Science & Engineering·Catalina-Paula SpatareluZi Chen
Aug 24, 2021·Physical Review Letters·G FaustiC Nardini
Aug 31, 2021·Current Opinion in Cell Biology·Elizabeth Lawson-Keister, M Lisa Manning

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