May 26, 2007

Softness, strength and self-repair in intermediate filament networks

Experimental Cell Research
Oliver I WagnerP A Janmey

Abstract

One cellular function of intermediate filaments is to provide cells with compliance to small deformations while strengthening them when large stresses are applied. How IFs accomplish this mechanical role is revealed by recent studies of the elastic properties of single IF protein polymers and by viscoelastic characterization of the networks they form. IFs are unique among cytoskeletal filaments in withstanding large deformations. Single filaments can stretch to more than 3 times their initial length before breaking, and gels of IF withstand strains greater than 100% without damage. Even after mechanical disruption of gels formed by crossbridged neurofilaments, the elastic modulus of these gels rapidly recovers under conditions where gels formed by actin filaments are irreversibly ruptured. The polyelectrolyte properties of IFs may enable crossbridging by multivalent counterions, but identifying the mechanisms by which IFs link into bundles and networks in vivo remains a challenge.

  • References55
  • Citations45

Citations

Mentioned in this Paper

Stress, Mechanical
Tonofilaments
Neurofilament
Myxine glutinosa
Hyrex Brand of Dimenhydrinate
Decompression Sickness
Aluminum Measurement
Projections and Predictions
Actins
Neurons

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.