Abstract
Ingestion of immature, environmentally stressed, or cultivar-specific Solanum species (particularly the potato) has been previously associated with gastrointestinal and neurological symptoms caused by solanaceous steroidal glycoalkaloids (SGAs). We report on two geographically, temporally disparate outbreaks of poisoning by susumber berries (Solanum torvum- Solanaceae) and on detection of alkaloids not present in non-toxic berries. Five family members in New York City participated in a traditional evening meal containing Jamaican susumber berries. All those consuming berries were symptomatic the following morning with varying degrees of gastrointestinal distress, dizziness, slurred speech, cranial nerve deficits, and ataxia. The most seriously afflicted patient developed hypertension, confusion, proximal upper extremity weakness, and hypercapnic respiratory failure requiring prolonged mechanical ventilation. A separate cohort of six patients in Toronto ate unripe Jamaican susumber berries. They presented 14h post-ingestion with varying degrees of diarrhea, weakness, facial paralysis, slurred speech, ataxia, early hypertension, and proximal weakness. Two patients had ventilatory decompensation; one required intubation. Poisonous...Continue Reading
References
Jan 3, 1992·Journal of Chromatography·K E HellenäsJ Gabrielsson
Dec 17, 1990·Cancer Letters·B E Cham, B Daunter
Nov 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P Slanina
Mar 1, 1985·Human Toxicology·M H HarveyH W Chan
May 1, 1971·Toxicology and Applied Pharmacology·K NishieA C Keyl
Nov 1, 1967·Planta medica·M B Fayez, A A Saleh
Jan 1, 1980·Critical Reviews in Food Science and Nutrition·J A Maga
Apr 1, 1981·Critical Reviews in Toxicology·S J JadhavD K Salunkhe
Aug 1, 1980·Journal of Steroid Biochemistry·W D ClaringboldJ H Renwick
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J R RayburnJ A Bantle
Jan 1, 1997·The Journal of Emergency Medicine·L J CehaT Erickson
May 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M D KrasowskiJ Moss
Jan 24, 1998·Biochemical and Biophysical Research Communications·L C ChangK W Kuo
Jul 14, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J T BlankemeyerM Friedman
Jul 26, 2000·Anesthesiology·D S McGeheeJ Moss
Dec 8, 2000·Biochemical Pharmacology·K W KuoH M Sheu
Nov 7, 2002·Chemical & Pharmaceutical Bulletin·Khalid A El Sayed, D Chuck Dunbar
Apr 3, 2003·Phytotherapy Research : PTR·Lina Al ChamiLuis LaCruz
Nov 7, 1958·Science·W H ORGELLP A DAHM
Nov 6, 2004·FEBS Letters·Li-Feng LiuKou-Wha Kuo
Jan 15, 2005·Regulatory Toxicology and Pharmacology : RTP·Tjeert T MensingaHans P van Egmond
Mar 15, 2006·Journal of Immunotherapy·Robbert G van der MostRichard A Lake
Jul 10, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L Y ShiuK W Kuo
Aug 21, 2007·Lancet·Michael EddlestonAndrew H Dawson
Jul 18, 2008·PLoS Medicine·Pradeepa JayawardaneNimal Senanayake
Jul 1, 1946·Physiological Reviews·O KRAYER, G H ACHESON
Citations
Nov 19, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Robert L GloverMichael Swerdlow
Aug 4, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Joan FuchsAlessandro Ceschi
Oct 23, 2010·Journal of Pharmaceutical and Biomedical Analysis·Karuna ShankerMadan M Gupta
Jun 24, 2015·Journal of Ethnopharmacology·Patrick Valere Tsouh FokouFabrice Fekam Boyom
Nov 14, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ilaria ProiettiAlberto Mantovani
Aug 24, 2010·Brazilian Journal of Biology = Revista Brasleira De Biologia·P M VieiraL Chen-Chen
Aug 14, 2020·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Bettina Grasl-Kraupp
Nov 11, 2010·Pharmaceutical Biology·Kinjal ChauhanSachin Parmar