Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy

Fitoterapia
Mahenina Jaovita ManaseMarie-Aleth Lacaille-Dubois

Abstract

A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-D-xylopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)-[O-α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including (1)H, (13)C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer cell lines and for antioxidant and cytoprotective activity.

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Citations

Mar 5, 2013·Tropical Animal Health and Production·James MadzimureBrighton M Mvumi
May 7, 2013·Journal of Ethnobiology and Ethnomedicine·Alfred Maroyi
Feb 11, 2014·Phytochemistry·Mahenina Jaovita ManaseMarie-Aleth Lacaille-Dubois
May 16, 2015·Food Chemistry·Gerardo Magela Vieira JúniorWagner Vilegas
Jun 4, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Atul GuptaArvind S Negi
Jul 21, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Marcel PetreanuJosé Roberto Santin
Sep 13, 2019·BioMed Research International·Longfei YangLufei Wang
Mar 15, 2019·Natural Products and Bioprospecting·Joseph Sakah Kaunda, Ying-Jun Zhang
Feb 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Desta Berhe Sbhatu, Haftom Baraki Abraha
Jul 12, 2017·Frontiers in Pharmacology·Jorge M Alves-SilvaLígia Salgueiro

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