PMID: 8972643Dec 1, 1996Paper

Solar-simulated ultraviolet irradiation induces selective influx of CD4+ T lymphocytes in normal human skin

Photochemistry and Photobiology
S Di NuzzoM B Teunissen

Abstract

The proportion and composition of the human cutaneous CD3+ T lymphocyte population was determined in situ following a single exposure to physiological, erythema-inducing doses of simulated solar radiation, mainly consisting of UV radiation. Biopsies were taken 1, 2 and 7 days after local irradiation of normal volunteers with 1, 2 and 4 MED by a xenonarc lamp and immunohistochemistry was performed on cryostat sections. Ultraviolet radiation caused an initial decrease of intraepidermal CD3+ T-cell numbers or even could lead to T-cell depletion 24 and 48 h postirradiation, and this was followed by an infiltration of T cells in the epidermis as determined 1 week after UV exposure. The number of dermal CD3+ T cells was increased 24 h after irradiation, reached a maximum at 48 h and subsequently declined at day 7, though remained significantly higher than the unirradiated control. Double staining demonstrated that the CD3+ T cells, which immigrated into the (epi)dermis upon UV exposure, coexpressed CD4 but not CD8. Therefore the CD4/CD8 ratio in skin was markedly increased during the first week upon UV exposure. Our time course study shows that UV radiation affects the T-cell population within human skin by depleting the majority of ...Continue Reading

References

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Citations

Nov 20, 2004·Archives of Dermatological Research·Gamze PiskinMarcel B M Teunissen
Feb 9, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Feiko RijkenPiet L B Bruijnzeel
Jun 3, 1999·The British Journal of Dermatology·M S DuthieM Norval
Oct 31, 2002·Photochemistry and Photobiology·Sergio Di NuzzoMarcel B M Teunissen
Jan 26, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rafael F SteliniFernanda Teixeira
Jun 26, 2021·The Journal of Investigative Dermatology·Shannon N EstadtJ Michelle Kahlenberg

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