PMID: 15331399Aug 28, 2004Paper

Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling

The American Journal of Pathology
Taihao QuanGary J Fisher

Abstract

Ultraviolet (UV) irradiation from the sun reduces production of type I procollagen (COLI), the major structural protein in human skin. This reduction is a key feature of the pathophysiology of premature skin aging (photoaging). Photoaging is the most common form of skin damage and is associated with skin carcinoma. TGF-beta/Smad pathway is the major regulator of type I procollagen synthesis in human skin. We have previously reported that UV irradiation impairs transforming growth factor-beta (TGF-beta)/Smad signaling in mink lung epithelial cells. We have investigated the mechanism of UV irradiation impairment of the TGF-beta/Smad pathway and the impact of this impairment on type I procollagen production in human skin fibroblasts, the major collagen-producing cells in skin. We report here that UV irradiation impairs TGF-beta/Smad pathway in human skin by down-regulation of TGF-beta type II receptor (TbetaRII). This loss of TbetaRII occurs within 8 hours after UV irradiation and precedes down-regulation of type I procollagen expression in human skin in vivo. In human skin fibroblasts, UV-induced TbetaRII down-regulation is mediated by transcriptional repression and results in 90% reduction of specific, cell-surface binding of TG...Continue Reading

Associated Clinical Trials

Sep 5, 2013·Sol Beatriz Jiménez

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Citations

Sep 29, 2011·Archives of Dermatological Research·Yun Kyung LeeSungkwan An
Apr 17, 2013·Journal of Dermatological Science·J FantasiaM D Southall
Dec 8, 2004·The Journal of Biological Chemistry·Taihao QuanGary J Fisher
Jul 15, 2009·Rejuvenation Research·Benjamin P Best
Mar 20, 2008·Plastic and Reconstructive Surgery·Richard J BrownThomas A Mustoe
Jun 30, 2009·Investigative Radiology·Narasimharao BhagavathulaJames Varani
Mar 13, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Young Bok LeeHyun Jeong Park
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Feb 8, 2014·Japanese Journal of Ophthalmology·Ying Liu, Ding Lin
Jul 17, 2014·Aesthetic Plastic Surgery·A AvantaggiatoF Carinci
Sep 18, 2014·Journal of Natural Medicines·Zheng-Wang SunTae Hoo Yi
Mar 26, 2009·Journal of Cell Communication and Signaling·Taihao QuanGary J Fisher
Mar 20, 2009·Connective Tissue Research·Miklós Sárdy
May 15, 2009·Photodermatology, Photoimmunology & Photomedicine·Julian M MenterNicolle V Martin
Apr 10, 2015·The Journal of Investigative Dermatology·Marco DemariaMichael C Velarde
Nov 1, 2007·Journal of Cellular Physiology·Chun-Lin ChenJung San Huang
Oct 8, 2014·Cell Biochemistry and Function·Haeyoung KwonSeyeon Park
Mar 13, 2014·BioMed Research International·Mamie Mizusaki IyomasaDaniela Mizusaki Iyomasa
Apr 18, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Gustavo DieamantLuiz Claudio Di Stasi

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