Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Mingming JinGang Huang

Abstract

Solasonine is a compound isolated from Solanum melongena that has anti-infection properties, and promotes neurogenesis. However, the use of solasonine for the treatment of hepatocellular carcinoma (HCC) has not yet been reported. So, the aim of this study was to assess the efficacy of solasonine for the treatment of HCC. The effects of solasonine were tested using the HCC cell lines HepG2 and HepRG. Metabolomics analysis was conducted to assess the effects of solasonine on tumor growth of nude mice xenografts using HepG2 cells. The data demonstrated that solasonine significantly suppressed proliferation of HepG2 and HepRG cells. A mouse xenograft model of HepG2 tumor formation confirmed that solasonine suppressed tumor volume and weight, and inhibited HCC cell migration and invasion, as determined with the Transwell and scratch wound assays. To further reveal the underlying regulatory mechanism, metabolomics analysis was performed. The results revealed the effects of solasonine on glutathione metabolism, including glutathione peroxidase 4 (GPX4) and glutathione synthetase (GSS). The glutathione-dependent lipid hydroperoxidase GPX4 prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols. Ferroptosis...Continue Reading

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Citations

Aug 11, 2020·Frontiers in Pharmacology·Xinyue LinYan Wu
Dec 30, 2020·Cancer Cell International·Yueyue YangJiayi Wang
May 18, 2021·Frontiers in Oncology·Yong XiaYoung Do Jung
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Hui WangAnwen Shao
Aug 29, 2021·Biochemical and Biophysical Research Communications·Lina HeYujuan Xiong
Sep 2, 2021·Journal of Hepatocellular Carcinoma·Hao LiaoZhiyu Xiao

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