Sole abnormalities of chromosome 7 in myeloid malignancies: spectrum, histopathologic correlates, and prognostic implications

American Journal of Hematology
Fareeda Taher Nazer HussainA Tefferi

Abstract

Among 6,565 consecutive abnormal cytogenetic reports at our institution, 3,192 (49%) constituted sole abnormalities, of which 230 (7%) involved chromosome 7: monosomy 7 (n = 98), 7q- (n = 51), der(1;7)(q10;p10) (n = 44), balanced translocations (n = 15), ring 7 (n = 13), and 7p- (n = 9). The most frequent histopathologic correlates were myelodysplastic syndromes (MDS; 28%), acute myeloid leukemia (AML; 17%), secondary or therapy-related MDS/AML (13%), primary myelofibrosis (PMF; 7%), and chronic myelomonocytic leukemia (6%). Monosomy 7 was the most frequent in each one of these disease categories except PMF where 7q- was more frequent. In primary MDS, patients with der(1;7)(q10;p10) (n = 13), compared to those with monosomy 7 (n = 30) or 7q- (n = 15), were less likely (P = 0.04) to display excess blasts or multilineage dysplasia but overall and leukemia-free survival adjusted for these variables revealed no significant difference between the three groups (P = 0.57 and 0.81, respectively). The current study does not prognostically distinguish monosomy 7 from 7q- or der(1;7), in MDS.

References

Apr 17, 2008·Annals of Hematology·Detlef Haase
Jul 17, 2009·American Journal of Clinical Pathology·Attilio Orazi, Magdalena B Czader
Nov 6, 2009·The New England Journal of Medicine·Ayalew Tefferi, James W Vardiman
Jul 1, 2011·Cancer·Iris CordobaUNKNOWN Spanish Myelodysplastic Syndrome Registry

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Citations

Nov 2, 2013·Current Hematologic Malignancy Reports·Danielle Marshall, Gail J Roboz
Apr 5, 2018·Blood·Toshiya InabaHirotaka Matsui
Nov 26, 2018·Journal of the Egyptian National Cancer Institute·Mohamed Amr M El-MenoufyNahla M Farahat
Jan 29, 2019·Frontiers in Immunology·Shinya RaiItaru Matsumura
Oct 30, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ruchi GuptaSoniya Nityanand

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