PMID: 8964764Mar 1, 1996Paper

Soleus fiber force and maximal shortening velocity after non-weight bearing with intermittent activity

Journal of Applied Physiology
Jeffrey J WidrickR H Fitts

Abstract

This study examined the effectiveness of intermittent weight bearing (IWB) as a countermeasure to non-weight-bearing (NWB)-induced alterations in soleus type I fiber force (in mN), tension (Po; force per fiber cross-sectional area in kN/m-2), and maximal unloaded shortening velocity (Vo, in fiber lengths/s). Adult rats were assigned to one of the following groups: normal weight bearing (WB), 14 days of hindlimb NWB (NWB group), and 14 days of hindlimb NWB with IWB treatments (IWB group). The IWB treatment consisted of four 10-min periods of standing WB each day. Single, chemically permeabilized soleus fiber segments were mounted between a force transducer and position motor and were studied at maximal Ca2+ activation, after which type I fiber myosin heavy-chain composition was confirmed by sodium dodecyl sufate-polyacrylamide gel electrophoresis. NWB resulted in a loss in relative soleus mass (-45%), with type I fibers displaying reductions in diameter (-28%) and peak isometric force (-55%) and an increase in Vo (+33%). In addition, NWB induced a 16% reduction in type I fiber Po, a 41% reduction in type I fiber peak elastic modulus [Eo, defined as (delta force/delta length) x (fiber length/fiber cross-sectional area] and a sign...Continue Reading

Citations

Jun 6, 1998·Journal of Applied Physiology·R H FittsJ J Widrick
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R H FittsJ J Widrick
Dec 21, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Scott TrappeTodd Trappe
Oct 18, 2013·Radiation Research·Alexander ShtifmanDavid A Goukassian
Jan 1, 2003·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki Yamazaki
Jan 1, 1998·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino
Apr 9, 2015·The Journal of Physiological Sciences : JPS·Takashi OhiraYoshinobu Ohira
Apr 5, 2018·Frontiers in Physiology·Yunfang GaoNandu Goswami
Dec 17, 2019·Acta Physiologica·Rizwan QaisarAdel B Elmoselhi
Jun 16, 2001·Journal of Applied Physiology·K Yamashita-GotoT Yoshioka
May 18, 2001·Journal of Applied Physiology·J J WidrickR H Fitts
May 9, 2002·American Journal of Physiology. Cell Physiology·Esther E Dupont-VersteegdenCharlotte A Peterson
Apr 14, 1999·The Journal of Physiology·J J WidrickR H Fitts
May 4, 2004·Journal of Applied Physiology·Jason C GalleglyEsther E Dupont-Versteegden
Apr 8, 2006·Journal of Applied Physiology·Esther E Dupont-VersteegdenCharlotte A Peterson
Aug 7, 2009·Journal of Cellular and Molecular Medicine·Angèle ChopardBernard J Jasmin
Aug 5, 2000·Journal of Applied Physiology·R H FittsJ J Widrick
Apr 13, 2002·The Journal of Orthopaedic and Sports Physical Therapy·Fuminari KanekoSerge H Roy
Nov 26, 2002·Acta Physiologica Scandinavica·J D FluckeyD Gaddy-Kurten
Jan 1, 2001·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino
Mar 16, 2002·Journal of Applied Physiology·Thierry TourselYvonne Mounier
Dec 15, 2004·Medicine and Science in Sports and Exercise·Jennifer E StevensKrista Vandenborne
Oct 8, 2004·American Journal of Physiology. Cell Physiology·D A RileyR H Fitts
Nov 27, 2002·Muscle & Nerve·Vincent J Caiozzo

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