Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging

PloS One
Annika S SahrmannGeoffrey G Handsfield

Abstract

Cerebral palsy (CP) is associated with movement disorders and reduced muscle size. This latter phenomenon has been observed by computing muscle volumes from conventional MRI, with most studies reporting significantly reduced volumes in leg muscles. This indicates impaired muscle growth, but without knowing muscle fiber orientation, it is not clear whether muscle growth in CP is impaired in the along-fiber direction (indicating shortened muscles and limited range of motion) or the cross-fiber direction (indicating weak muscles and impaired strength). Using Diffusion Tensor Imaging (DTI) we can determine muscle fiber orientation and construct 3D muscle architectures which can be used to examine both along-fiber length and cross-sectional area. Such an approach has not been undertaken in CP. Here, we use advanced DTI sequences with fast imaging times to capture fiber orientations in the soleus muscle of children with CP and age-matched, able-bodied controls. Cross sectional areas perpendicular to the muscle fiber direction were reduced (37 ± 11%) in children with CP compared to controls, indicating impaired muscle strength. Along-fiber muscle lengths were not different between groups. This study is the first to demonstrate along-f...Continue Reading

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Citations

Sep 14, 2021·Frontiers in Bioengineering and Biotechnology·Stephanie KhuuGeoffrey G Handsfield

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Methods Mentioned

BETA
imaging techniques
dissection

Software Mentioned

Matlab
DSI studio
ITK Snap

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