Solid cell nests of the thyroid gland: morphological, immunohistochemical and genetic features

Histopathology
Marco ManzoniFabio Pagni

Abstract

The correct identification of solid cell nests (SCNs) is an important issue in thyroid pathology because of the spectrum of differential diagnoses of this type of lesion. Ten cases of 295 consecutive thyroidectomies showed the presence of SCNs at histological examination. The identification of the exact SCN type required the distinction of the cystic and solid pattern; SCNs were usually composed of a mixture of main cells (MCs) and C-cells (CCs). The immunohistochemical calcitonin stain identified CCs easily, both inside SCNs and dispersed in islets at the periphery. For the characterization of MCs, we added the utility of p40 to p63. The use of thyroid transcription factor-1 (TTF-1) helped in their identification, as MCs did not react with this marker; the combination of TTF-1 and p40 or p63 IHC stains was useful for the characterization of cystic SCNs of both types 3 and 4. The negativity of mouse monoclonal mesothelioma antibody (HMBE-1) and a very low proliferative index (MIB-1) supported the diagnosis. [Correction added on 23 November 2015, after online publication: MIB-1 was incorrectly defined, the expanded form was deleted.] We discourage the use of galectin-3 (Gal-3) and cytokeratin-19 (CK-19), as they have an importan...Continue Reading

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Citations

Apr 15, 2016·Endocrine Pathology·Marco ManzoniFabio Pagni
Feb 8, 2019·International Journal of Surgical Pathology·David CreytensJo Van Dorpe
Aug 5, 2020·International Journal of Surgical Pathology·K K W YuenW Cheuk
Sep 28, 2017·Pathology International·Hiroyuki YamamotoHiroshi Kamma
Dec 6, 2018·International Journal of Molecular Sciences·Veronica Vella, Roberta Malaguarnera
Jul 22, 2017·Virchows Archiv : an International Journal of Pathology·Kristyna SrbeckaOndrej Daum
May 11, 2018·Endocrine Pathology·Zubair BalochSylvia L Asa

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