Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Frontiers in Molecular Biosciences
Sebastián Scioli MontotoMaría Esperanza Ruiz

Abstract

In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of the original concepts and ideas. There is no doubt that nanoformulations are extremely valuable tools for drug delivery applications; the current challenge is how to optimize them to ensure that they are safe, effective and scalable, so that they can be manufactured at an industrial level and advance to clinical use. In this context, lipid nanoparticles have gained ground, since they are generally regarded as non-toxic, biocompatible and easy-to-produce formulations. Pharmaceutical applications of lipid nanocarriers are a burgeoning field for the transport and delivery of a diversity of therapeutic agents, from biotechnological products to small drug molecules. This review starts with a brief overview of the characteristics of solid lipid nanoparticles and discusses the relevancy of performing systematic preformulation studies. The main applications, as well as the advantages that this type of nanovehicles offers in certain therapeutic scenarios are discussed. Next, pharmacokinetic aspects are described, such as routes of administration, absorption after oral administration, distribution in the organism (including brain penetration) and el...Continue Reading

References

Apr 20, 2001·Advanced Drug Delivery Reviews·W Mehnert, K Mäder
May 31, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Caitriona M O'Driscoll
Aug 15, 2002·International Journal of Pharmaceutics·R H MüllerS A Wissing
Aug 23, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andrea GessnerRainer Müller
Oct 3, 2002·Nature Reviews. Genetics·Michael T McManus, Phillip A Sharp
Oct 28, 2003·Journal of Drug Targeting·Torsten M Göppert, Rainer H Müller
Feb 6, 2004·Nature Biotechnology·Angela ReynoldsAnastasia Khvorova
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Jul 6, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Torsten M Göppert, Rainer H Müller
Sep 10, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chao FangHong-Zhuan Chen
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jan 31, 2009·Nature Reviews. Drug Discovery·Kathryn A WhiteheadDaniel G Anderson
Mar 17, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anja ZensiJörg Kreuter
Jun 10, 2009·Current Neuropharmacology·Svetlana M StamatovicAnuska V Andjelkovic
Mar 17, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gaurav SahayAlexander V Kabanov
Jan 1, 2009·Critical Reviews in Therapeutic Drug Carrier Systems·Anu PuriRobert Blumenthal
Jun 23, 2011·Small·Jin WangJoseph M DeSimone
Nov 13, 2012·The AAPS Journal·Subash C GuptaBharat B Aggarwal
Jan 22, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cornelia M Keck, Rainer H Müller
Mar 5, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vandita KakkarIndu Pal Kaur
Apr 5, 2013·Expert Opinion on Drug Delivery·Medha PatelKamalinder K Singh
Apr 6, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Harshad VaghasiyaKrutika Sawant
Sep 24, 2013·BioMed Research International·Praveen Kumar GaurSuresh Purohit
Nov 15, 2013·BioMed Research International·Anand Kumar KushwahaSanjay Singh
Nov 28, 2013·Current Drug Delivery·Sandipan DasguptaBhaskar Mazumder
Feb 5, 2014·Pharmaceutical Development and Technology·Biswaranjan MohantySoma Patnaik
Apr 25, 2014·Journal of Nanoscience and Nanotechnology·Tuan Hiep TranJong Oh Kim
May 3, 2014·Drug Discovery Today·Udita AgrawalSuresh P Vyas
May 9, 2014·Journal of Biomedical Nanotechnology·Stephânia F TaveiraRenata F V Lopez
Jun 28, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tingting FanYuan Huang

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Citations

Feb 5, 2021·International Journal of Pharmaceutics·Aldemar Gordillo-GaleanoClaudia Elizabeth Mora-Huertas
Mar 4, 2021·International Journal of Molecular Sciences·Lyes ToualbiMariya Moosajee
Mar 29, 2021·Advanced Drug Delivery Reviews·Souhaila H El MoukhtariMaría J Blanco-Prieto
May 14, 2021·Frontiers in Chemistry·Neerupma DhimanGiriraj T Kulkarni
May 13, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kuan-Ju ChenDavid Cipolla
Jun 15, 2021·International Journal of Biological Macromolecules·Srividya GorantlaGautam Singhvi
Jun 19, 2021·Frontiers in Molecular Biosciences·Satabdi Datta Choudhury
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tejashree WaghuleGautam Singhvi
Aug 2, 2021·International Journal of Pharmaceutics·Usri H IbrahimThirumala Govender
Sep 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Janaina de Alcantara LemosAndre Luis Branco de Barros
Sep 23, 2021·Expert Review of Vaccines·Amrita Das, Nahid Ali

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Clinical Trials Mentioned

NCT01960348
NCT01858935
NCT02227459
NCT01437007
NCT04416126
NCT04442347
NCT03323398
NCT03739931
NCT04283461
NCT02971007

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