Solid lipid nanoparticles for encapsulation of hydrophilic drugs by an organic solvent free double emulsion technique

Colloids and Surfaces. B, Biointerfaces
Luana Becker PeresClaudia Sayer

Abstract

Encapsulation of hydrophilic compounds for drug delivery systems with high loading efficiency is not easily feasible and remains a challenge, mainly due to the leaking of the drug to the outer aqueous phase during nanoparticle production. Usually, encapsulation of hydrophilic drugs is achieved by using double emulsion or inverse miniemulsion systems that often require the use of organic solvents, which may generate toxicological issues arising from solvent residues. Herein, we present the preparation of solid lipid nanoparticles loaded with a hydrophilic compound by a novel organic solvent free double emulsion/melt dispersion technique. The main objective of this study was to investigate the influence of important process and formulation variables, such as lipid composition, surfactant type, sonication parameters and lipid solidification conditions over physicochemical characteristics of SLN dispersion. Particle size and dispersity, as well as dispersion stability were used as responses. SLN dispersions with average size ranging from 277 to 550 nm were obtained, showing stability for over 60 days at 4 °C depending on the chosen emulsifying system. Entrapment efficiency of fluorescent dyes used as model markers was assessed by f...Continue Reading

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Citations

Aug 30, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Róbert LehockýFrantišek Štěpánek
Dec 17, 2019·Pharmaceutical Nanotechnology·Giulia AnderluzziYvonne Perrie
Nov 1, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Uday Krishna BaruahPhanithi Prakash Babu
Nov 14, 2019·Pharmaceutics·Marcin MakowskiNuno C Santos
Aug 2, 2018·Bioengineering & Translational Medicine·Maya MonroeHonggang Cui
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Van-An DuongHan-Joo Maeng
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Arthur Poester CordeiroClaudia Sayer
Feb 16, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Namratha Turuvekere Vittala MurthyHarsh Chauhan
Nov 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Giulia AnderluzziYvonne Perrie
Feb 18, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mukta AgrawalAmit Alexander
Oct 16, 2019·Advances in Colloid and Interface Science·Qixin Zhong, Linhan Zhang
May 18, 2021·BioMed Research International·Parisa Abbasi FarsaniMohammad Mehdi Mahboobian
May 29, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yashika MirchandaniBrijesh S
May 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·María Gabriela Villamizar-SarmientoFelipe A Oyarzun-Ampuero
Jun 29, 2021·Seminars in Cancer Biology·Xiao Yin MaFei Wen
Aug 2, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Adriana TrapaniMassimo Conese

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