Solid Lipid Nanoparticles Formulated for Transdermal Aconitine Administration and Evaluated In Vitro and In Vivo

Journal of Biomedical Nanotechnology
Yongtai ZhangNianping Feng

Abstract

In this study, solid lipid nanoparticles were formulated for transdermal delivery of aconitine to improve its safety and permeability. Aconitine-loaded solid lipid nanoparticles were formulated as an oil-in-water microemulsion. Drug encapsulation efficiencies for these formulations were higher than 85%, and correlated positively with levels of surfactant and oil matrix. The size of the solid lipid nanoparticles was increased with an increase of the oil matrix, and reduction of the surfactant levels. Compared with an ethanol tincture, all the tested solid lipid nanoparticle formulations achieved improved transdermal fluxes and drug deposition in skin in vitro. Real-time monitoring of drug distribution in rat dermis using in vivo microdialysis showed that aconitine concentration was markedly higher following application of solid lipid nanoparticles, compared to tincture, throughout the experimental period. A regional comparison of rat skin found that application of solid lipid nanoparticles to the scapular region resulted in higher AUC(0-t) and C(max), compared to those achieved with application to the abdomen or chest (p < 0.05). In contrast, the application to the chest resulted in the lowest AUC(0-t) and C(max). Together with ...Continue Reading

Citations

Feb 18, 2020·Expert Opinion on Drug Delivery·Eliana B SoutoSheefali Mahant
Nov 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Roxana JijieSabine Szunerits
Sep 14, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Teng GuoNianping Feng
Jan 27, 2021·International Journal of Pharmaceutics·Ricardo LorenzoniSilvia Stanisçuaski Guterres
Aug 8, 2021·International Journal of Molecular Sciences·Maddalena SguizzatoRita Cortesi

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