PMID: 26328443Sep 4, 2015Paper

Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris

Journal of Nanoscience and Nanotechnology
Elton Luiz SilvaLucas Antônio Miranda Ferreira

Abstract

Topical therapy is the first choice for the treatment of mild to moderate acne and all-trans retinoic acid is one of the most used drugs. The combination of retinoids and antimicrobials is an innovative approach for acne therapy. Recently, lauric acid, a saturated fatty acid, has shown strong antimicrobial activity against Propionibacterium acnes. However, topical application of retinoic acid is followed by high incidence of side-effects, including erythema and irritation. Solid lipid nanoparticles represent an alternative to overcome these side-effects. This work aims to develop solid lipid nanoparticles loaded with retinoic acid and lauric acid and evaluate their antibacterial activity. The influence of lipophilic stearylamine on the characteristics of solid lipid nanoparticles was investigated. Solid lipid nanoparticles were characterized for size, zeta potential, encapsulation efficiency, differential scanning calorimetry and X-ray diffraction. The in vitro inhibitory activity of retinoic acid-lauric acid-loaded solid lipid nanoparticles was evaluated against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. High encapsulation efficiency was obtained at initial time (94 ± 7% and 100 ± 4% for ret...Continue Reading

Citations

Mar 8, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joshua A JackmanNam-Joon Cho
Sep 14, 2018·Current Drug Delivery·Sandra Sherif AmerOmaima Sammour
Apr 13, 2018·International Journal of Molecular Sciences·Bo Kyeong YoonNam-Joon Cho
Feb 18, 2020·Expert Opinion on Drug Delivery·Eliana B SoutoSheefali Mahant
Apr 19, 2017·FEMS Microbiology Reviews·Michal Natan, Ehud Banin
Feb 11, 2020·Drug Delivery·Samah Attia AlgharibShuyu Xie
Nov 29, 2016·Expert Opinion on Drug Delivery·Mariana Silva OliveiraGuilherme Carneiro
May 30, 2020·Molecular Pharmaceutics·Mingyue CuiChenjie Xu
Feb 18, 2020·International Journal of Pharmaceutics·Rinaldo Patel, Priyanka Prabhu
Apr 19, 2020·Current Pharmaceutical Design·Myla Lôbo de SouzaPedro José Rolim-Neto
Jul 3, 2021·Expert Opinion on Drug Delivery·Ana Cláudia Paiva-SantosFrancisco Veiga

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