Solid organ donation from the emergency department - A systematic review

CJEM
Jessica McCallumIan G Stiell

Abstract

A significant gap exists between people awaiting an organ transplant and organ donors. The purpose of this study was to determine what percent of successful donors come from the emergency department (ED), whether there are any missed donors, and to identify factors associated with successful and missed donation. This systematic review used electronic searches of EMBASE, MEDLINE, and CINAHL according to PRISMA guidelines on July 7, 2017. We included primary literature in adults describing successful and missed organ donation. Two authors independently screened articles, and discrepancies were resolved through consensus. Quality was assessed using the STROBE checklist. This systematic review identified 1,058 articles, and 25 articles were included. For neurologic determination of death, ED patients comprised 4%-50% of successful donors and 3.6%-8.9% of successful donors for donation after circulatory determination of death. ED death reviews revealed up to 84% of missed neurologic determination of death, and 46.2% of missed circulatory determination of death donors who died in the ED are missed due to a failure to refer for consideration of organ donation. Clinical heterogeneity precluded pooling of the data to conduct a meta-anal...Continue Reading

References

Nov 1, 1991·The Journal of Emergency Medicine·R R Riker, B W White
Jan 1, 1998·Transplantation Proceedings·G Kootstra
Apr 26, 2005·Transplantation Proceedings·C J BroombergD Kahn
Jun 29, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nicole A Tenn-LynDan E Cass
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Aug 14, 2009·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Glen E Michael, Robert E O'Connor
Sep 12, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Gurch RandhawaVivienne Parry
Nov 3, 2010·The American Journal of Emergency Medicine·Philippe Le ConteGilles Potel
Oct 18, 2011·American Journal of Surgery·Mustafa RaoofPeter Rhee
Oct 3, 2012·Transplantation Proceedings·C M Dell AgnoloS M Pelloso
May 6, 2014·American Journal of Surgery·Lisabeth D MillerK Dean Gubler
Feb 18, 2016·The Journal of Trauma and Acute Care Surgery·Katie M LoveGlen A Franklin
Mar 19, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·M ThuongR J Ploeg
May 3, 2016·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Michael A DeVitaSusan Stuart
Mar 7, 2017·Journal of the American College of Surgeons·Abdul Q AlarhayemBrian J Eastridge
Apr 4, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M WitjesW F Abdo
Apr 25, 2017·Transplantation·Sam D ShemieUNKNOWN EOL Conversations with Families of Potential Donors participants.
Mar 20, 2018·The Journal of Trauma and Acute Care Surgery·Adam CameronRobert S Green
May 22, 2018·Critical Care Medicine·Janet E SquiresGregory A Knoll
Jul 28, 2018·Transplantation Reviews·Anne C van ErpHenri G D Leuvenink

❮ Previous
Next ❯

Citations

Sep 26, 2019·CJEM·Andrew Healey, Jeffrey M Singh
Sep 26, 2020·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Kahyun KimYoun Jung Lee
Aug 3, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Noah KrampeJavier Povar Marco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.