Solid organ transplantation in survivors of hematopoietic cell transplantation: a single institution case series and literature review

Clinical Transplantation
Amer BeitinjanehNavneet S Majhail

Abstract

For selected hematopoietic cell transplant (HCT) survivors with severe organ dysfunction, solid organ transplantation (SOT) may offer the best chance for better quality of life and extended survival. However, SOT following HCT has not been well described. We report our institutional experience of SOT in 12 HCT recipients and present a review of the published literature of this procedure in HCT survivors. Our experience with transplanted organs included kidney (n=7), lung (n=3), liver (n=2) and heart (n=1). Age at HCT ranged from 2 to 56 yr. Median time between HCT and SOT was 7.9 yr (range 1.2-15.9 yr). Among the 11 patients with post-SOT follow-up information, 10 had normal function of the transplanted solid organ at the time of last contact or death. Infections and secondary malignancy were the most common complications. Four other institutional experiences with kidney transplant, 21 case reports of liver transplant, 11 case reports of lung transplant and one cardiac transplant are also summarized. SOT is feasible for selected HCT survivors with organ failure and may be associated with favorable long-term survival and graft function. More research is needed to further delineate the subset of survivors who will benefit the mos...Continue Reading

References

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Citations

Sep 26, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin MynarekBritta Maecker-Kolhoff
Dec 15, 2010·Seminars in Nephrology·Eric P CohenJohn E Moulder
Jun 9, 2016·The New England Journal of Medicine·Sangeeta Hingorani
Jul 15, 2015·Cell Transplantation·Olga BaraldiGaetano La Manna
Jun 15, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael EderRainer Oberbauer
Jan 13, 2018·Journal of Oncology Practice·Philip J Bierman
Sep 20, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Najla El JurdiDaniel J Weisdorf
Dec 10, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David W ChittyVinay Nair
Jun 29, 2021·Frontiers in Immunology·Priscila Ferreira SlepickaAlice Bertaina

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