Solid-phase chemoenzymatic synthesis of C-sialosides

The Journal of Organic Chemistry
Sultan N BaytasR J Linhardt

Abstract

The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.

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Citations

Jan 18, 2007·Chemical Society Reviews·Lisa A Sloan, David J Procter
Apr 23, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danilo Mirizzi, Maurizio Pulici
Sep 16, 2017·Chemical Reviews·You Yang, Biao Yu
Nov 15, 2005·Journal of Combinatorial Chemistry·Roland E Dolle

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