Solid-phase extraction-high-performance liquid chromatography-ion trap mass spectrometry for analysis of trace concentrations of macrolide antibiotics in natural and waste water matrices

Journal of Chromatography. a
S Yang, K H Carlson

Abstract

A method using solid-phase extraction (SPE) combined with high-performance liquid chromatography-ion trap tandem mass spectrometry (LC-MS-MS) has been developed for determination of trace concentrations of erythromycin-H2O (ETM-H2O), roxithromycin (RTM) and tylosin (TLS) in natural and waste water matrices. These macrolides (MLs) were extracted from water samples using Oasis HLB cartridges, and the average recovery was 93.6 +/- 8.6, 92.1 +/- 10.0, and 94.3 +/- 8.9% for ETM-H2O, RTM and TLS in surface water, respectively. For water from the influent of a wastewater treatment plant (WWTP), the average recovery was 84.8 +/- 14.0, 83.2 +/- 13.1, and 86.1 +/- 13.4% for ETM-H2O, RTM and TLS, respectively. Method detection limits in a natural water matrices were 0.07, 0.03, and 0.05 microg/l for ETM-H2O, RTM, and TLS, respectively. Fragment or product ions from MS spectra using in-source collision-induced dissociation and MS-MS spectra have been identified. The accuracy and day-to-day variation of the method fell within acceptable ranges. The method was evaluated by studying the occurrence of the three macrolides on a river and a WWTP in northern Colorado. None of the antibiotics were detected in the stream except immediately downstre...Continue Reading

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Citations

May 19, 2006·Analytical and Bioanalytical Chemistry·M Silvia Díaz-Cruz, Damià Barceló
Jul 19, 2006·Analytical and Bioanalytical Chemistry·Sung-Chul Kim, Kenneth Carlson
Mar 10, 2010·Analytical and Bioanalytical Chemistry·A PenaP Solich
Nov 11, 2010·Analytical and Bioanalytical Chemistry·Despo Fatta-KassinosAnastasia Nikolaou
Nov 30, 2013·Environmental Science and Pollution Research International·Jinjin WanShengxiang Zhang
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Nazmiye GunesLevent Aydin
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Jan 29, 2008·The Science of the Total Environment·Fatima TamtamMarc Chevreuil
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Aug 25, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jie DingNanqi Ren
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Dec 1, 2007·Rapid Communications in Mass Spectrometry : RCM·Svetlana GrujicTeodor Ast
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Jun 15, 2005·Analytical Chemistry·Susan D Richardson, Thomas A Ternes

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