Solid phase microextraction devices prepared on plastic support as potential single-use samplers for bioanalytical applications

Analytical Chemistry
Nathaly Reyes-GarcésJanusz Pawliszyn

Abstract

This study presents new thin-film solid phase microextraction (SPME) devices prepared on plastic as potential single-use samplers for bioanalysis. Polybutylene terephthalate (PBT) was selected as a support due to its well-known chemical resistance, low cost, and suitability as a material for different medical grade components. The herein proposed samplers were prepared by applying a hydrophilic-lipophilic balanced (HLB)-polyacrylonitrile (PAN) coating on rounded and flat PBT pieces previously sanded with regular sandpaper. SPME devices prepared on PBT were evaluated in terms of robustness, chemical stability, and possible interferences upon exposure to different solvents and matrixes. Rewarding results were found when these samplers were employed for the quantitative analysis of multiple doping substances in common biological matrixes such as urine, plasma, and whole blood. Finally, the proposed thin-film SPME devices made on a PBT were evaluated by conducting multiple extractions from whole blood and plasma using the Concept 96 system. Results showed that more than 20 extractions from plasma and whole blood can be performed without observed decreases in coating performance or peeling of the extraction phase from the plastic su...Continue Reading

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Citations

Dec 10, 2015·Analytical Chemistry·German A Gomez-RiosJanusz Pawliszyn
May 29, 2016·Journal of Pharmaceutical and Biomedical Analysis·Krzysztof GoryńskiBarbara Bojko
Apr 19, 2016·Expert Opinion on Drug Metabolism & Toxicology·Suzanne L ParkerJason A Roberts
Mar 3, 2017·Environmental Science & Technology·Fardin AhmadiJanusz Pawliszyn
Nov 25, 2017·Scientific Reports·Germán Augusto Gómez-RíosJanusz Pawliszyn
Jan 22, 2019·Bioanalysis·Gabriela de Oliveira SilveiraMauricio Yonamine
May 5, 2018·Scientific Reports·Anna RoszkowskaJanusz Pawliszyn
Jan 30, 2018·Bioanalysis·Germán Augusto Gómez-RíosJanusz Pawliszyn
Dec 26, 2018·Critical Reviews in Analytical Chemistry·Muhammad SajidJustyna Płotka-Wasylka
Feb 14, 2017·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Cunling YeZhike Wang
Jan 13, 2021·Journal of Separation Science·Mohammad Mahdi KhataeiMaryam Shamsayei
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Łukasz SobczakKrzysztof Goryński
Aug 21, 2019·Analytical Chemistry·Alexander KasperkiewiczJanusz Pawliszyn

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