Solid-phase microextraction-gas chromatography-mass spectrometry for the analysis of selective serotonin reuptake inhibitors in environmental water

Journal of Chromatography. a
J Pablo LamasMariano Gómez

Abstract

The continuous contamination of surface waters by pharmaceuticals is of most environmental concern. Selective serotonin reuptake inhibitors (SSRIs) are drugs currently prescribed for the treatment of depressions and other psychiatric disorders and then, they are among the pharmaceuticals that can occur in environmental waters. Solid-phase microextraction (SPME) coupled to gas chromatography-mass spectrometry has been applied to the extraction of five SSRIs--venlafaxine, fluvoxamine, fluoxetine, citalopram and sertraline--from water samples. Some of the analytes were not efficiently extracted as underivatized compounds and so, an in situ acetylation step was introduced in the sample preparation procedure. Different parameters affecting extraction efficiency such as extraction mode, fiber coating and temperature were studied. A mixed-level fractional factorial design was also performed to simultaneously study the influence of other five experimental factors. Finally, a method based on direct SPME at 100 degrees C using polydimethylsiloxane-divinylbenzene fibers is proposed. The performance of the method was evaluated, showing good linearity and precision. The detection limits were in the sub-ng/mL level. Practical applicability w...Continue Reading

References

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Citations

Feb 24, 2006·Analytical and Bioanalytical Chemistry·José Benito Quintana, Isaac Rodríguez
Aug 28, 2012·Journal of Pharmacy & Bioallied Sciences·Janet Mifsud, Lino J Sghendo
Apr 5, 2008·Bulletin of Environmental Contamination and Toxicology·Jeong-Wook Kwon, Kevin L Armbrust
Feb 23, 2010·Chemosphere·Emily M SmithJoanna Y Wilson
Dec 22, 2009·Environment International·Silvia González AlonsoYolanda Valcárcel
Nov 5, 2008·Journal of Pharmaceutical and Biomedical Analysis·M Espinosa BoschC Bosch Ojeda
Sep 8, 2010·Environmental Toxicology and Chemistry·Chris D MetcalfeDavid M Andrews
Sep 4, 2012·The Science of the Total Environment·Liliana J G SilvaAngelina Pena
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Jun 4, 2016·Marine Environmental Research·Noelia Estévez-CalvarFrancesca Garaventa
Feb 23, 2008·Critical Reviews in Clinical Laboratory Sciences·Sarah M R WilleWilly E E Lambert
Mar 31, 2005·Journal of Pharmaceutical and Biomedical Analysis·Jeong-Wook Kwon, Kevin L Armbrust
Jan 23, 2020·Environmental Technology·Stavros G PoulopoulosConstantine J Philippopoulos
Feb 8, 2011·Journal of Separation Science·Paulo Clairmont Feitosa de Lima GomesFernando Mauro Lancas
Jul 14, 2017·Environmental Science and Pollution Research International·Minghong WuGang Xu
May 31, 2017·Bulletin of Environmental Contamination and Toxicology·Elif Seda KoçoğluSeyfullah Keyf
Sep 19, 2007·Journal of Chromatography. a·Evelyn L McClure, Charles S Wong
Sep 1, 2016·Journal of Chromatography. a·Ernest Darko, Kevin B Thurbide

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