Solid-phase microextraction (SPME) calibration using inkjet microdrop printing for direct loading of known analyte mass on to SPME fibers

Analytical and Bioanalytical Chemistry
Sigalit GuraJosé R Almirall

Abstract

Solid-phase microextraction (SPME) is a widely used sampling technique that has been proved to enable efficient extraction of a broad range of analytes. Generally, SPME achieves non-exhaustive extraction, and therefore the analyte mass transfer distribution in the sampled multiphase system should be considered while developing a calibration method. Here, a new method, aimed at quantifying the extracted analytes without the need to consider their mass distribution, is proposed. This method relies on the generation of mass response curves by loading a known analyte mass onto the absorbent phase of a SPME fiber, and then conducting analysis by the preferred technique. Precise and accurate deposition of analyte over the restricted dimension of a fiber is demonstrated for the first time by utilizing a drop-on-demand microdrop printer. This system enables direct, non-contact deposition of micron-sized drops containing negligible solvent volumes (<1 nL), on the center of the extraction phase of the fiber which enables immediate analysis. Printed fiber response curves were determined herein, with three model compounds of different volatility-2,4-dinitrotoluene (2,4-DNT), diphenylamine (DPA), and 1,3 diethyl-1,3-diphenylurea (ethyl cent...Continue Reading

References

Jul 13, 2000·Journal of Chromatography. a·H KataokaJ Pawliszyn
Jul 30, 2003·Journal of Chromatography. a·L J KrutzA S Sciumbato
Mar 10, 2005·Journal of Separation Science·Jeannette M PerrJosé R Almirall
Oct 21, 2005·The Breast : Official Journal of the European Society of Mastology·N SteeleD Cameron
Nov 22, 2005·Journal of Chromatography. a·Gangfeng OuyangJanusz Pawliszyn
May 5, 2006·Analytical and Bioanalytical Chemistry·Gangfeng Ouyang, Janusz Pawliszyn
Jun 6, 2007·Analytical and Bioanalytical Chemistry·Matthias EnglmannPhilippe Schmitt-Kopplin
Sep 24, 2008·Analytica Chimica Acta·Gangfeng Ouyang, Janusz Pawliszyn
Oct 7, 2008·Analytical and Bioanalytical Chemistry·Sanja RisticevicJanusz Pawliszyn
May 5, 2009·Forensic Science International : Synergy·Monica JoshiJosé R Almirall
Oct 15, 2009·Analytical Chemistry·R Michael Verkouteren, Jennifer R Verkouteren

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