PMID: 702117Jan 1, 1978Paper

Solid-phase radioimmunoassay determination of virus-specific IgM antibody levels in a follow-up patients with naturally acquired measles infections

Journal of Medical Virology
T VuorimaaP E Halonen

Abstract

The question of the exact disappearance time or possible persistence of measles-specific IgM antibodies after naturally acquired measles virus infections was studied with a sensitive solid-phase radioimmunoassay (RIA) method. A total of 30 patients were analyzed with follow-up times varying from 4.5 to 8 months; all were measles IgM positive in the first serum specimen obtained after the onset of rash. In 29 of 30 patients, the measles IgM declined to undetectable levels by approximately 90 days. The remaining patient developed postmeasles encephalitis, however, and was found to have a prolonged measles IgM antibody response. For comparison, the measles-specific IgG response was also studied and was found to develop only slightly later than the IgM response, with levels then remaining high and stable up to 8 months later. Although apparent measles IgM antibodies were found in 1 of 64 nonmatched adult controls, they were due to the presence of high levels of IgM-class rheumatoid factor. The data presented indicate that measles IgM antibodies begin to decline soon after the onset of rash and reach negative levels 1 to 3 months later; in complicated infections, however, measles IgM antibody synthesis may not terminate normally.

References

Jan 1, 1977·The Journal of General Virology·P ArstilaP Toivanen
Jan 2, 1971·British Medical Journal·J H ConnollyD S Hadden
May 15, 1971·British Medical Journal·J H MillarD S Hadden
Aug 19, 1972·British Medical Journal·K B FraserJ H Millar

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Citations

Jan 1, 1983·Medical Microbiology and Immunology·H Tuokko, A Salmi
Sep 1, 1983·Diagnostic Microbiology and Infectious Disease·M B KleimanL J Wheat
Mar 11, 1998·The Pediatric Infectious Disease Journal·B P QuiambaoP Ruutu
Apr 1, 1979·Japanese Journal of Medical Science & Biology·H SakataY Kuroiwa
Jan 1, 1984·Journal of Medical Virology·M ZapataM A Chernesky
Feb 1, 1983·The Journal of Pediatrics·A S YeagerP E Halonen
Dec 13, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Geoff CohenRobertson Parkman
Apr 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·I R PedersenC H Mordhorst
Apr 15, 1983·Journal of Immunological Methods·A BonioloM Zannino
Mar 26, 1982·Journal of Immunological Methods·B ZiolaK Penttinen

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