Solid-phase staudinger ligation from a novel core-shell-type resin: a tool for facile condensation of small peptide fragments

Organic Letters
Hanyoung KimYoon-Sik Lee

Abstract

[reaction: see text] Solid-phase Staudinger ligation of small peptides was performed on a novel core-shell-type resin. Solid-phase Staudinger ligation was mediated by synthetic solid-supported phosphinothiol, which was readily prepared by a straightforward synthetic route. This protocol afforded final peptide products in excellent yields and purities and thus could provide the opportunity to facilitate a simple manipulation for condensation of peptide fragments. In particular, the resulting resin could be recycled in a successful manner.

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Aug 24, 2007·Journal of the American Chemical Society·Annie TamRonald T Raines
Dec 16, 2006·The Journal of Organic Chemistry·Matthew B SoellnerRonald T Raines
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