PMID: 15460439Oct 6, 2004Paper

Solid phase synthesis of 3-(4-hydroxyphenyl)coumarin: preliminary experiments for combinatorial synthesis of substituted 3-phenylcoumarin derivatives

Archives of Pharmacal Research
Hoon Bae, Hak Sung Kim


Coumarin and its derivatives occur widely in nature. Many attempts were made for synthesis of various coumarin derivatives because of their interesting biological activities. In this study, solid phase synthetic approach of 3-(4-hydroxyphenyl)coumarin was achieved for combinatorial synthesis of substituted 3-phenylcoumarin analogues. Starting from 4-hydroxyphenylacetic acid methyl ester, release of 3-(4-hydroxypnehyl)coumarin from polymer support was accomplished.


May 26, 1976·Journal of the American Chemical Society·M S NewmanD R Olson
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Dec 1, 1996·Journal of Natural Products·A M SilvánA Villar
May 23, 2000·Planta medica·A N García-ArgáezM Martínez-Vázquez
Aug 12, 2000·Phytochemistry·W MaierD Strack

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