Solid-phase synthesis of lipidated Ras peptides employing the Ellman sulfonamide linker

Chemistry : a European Journal
Gemma TriolaHerbert Waldmann

Abstract

A detailed study on the solid-phase synthesis of lipidated peptides of the Ras family employing the Ellman sulfonamide linker is reported. Using the C-terminal N-Ras sequence, critical issues such as lipidated amino acid resin loading, peptide elongation in the presence of labile groups and optimized conditions for release of the peptides were investigated. A versatile methodology for the synthesis of peptides with diverse lipid motifs and C-terminal methyl esters has accordingly been established.

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Citations

Oct 13, 2017·Current Medicinal Chemistry·Anutthaman ParthasarathyKarunakaran A Kalesh
Apr 18, 2017·The Journal of Organic Chemistry·Andrea TemperiniCarlo Siciliano
Jul 23, 2016·Bioconjugate Chemistry·Tom Mejuch, Herbert Waldmann

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