Solid-phase synthesis of second-generation polyproline dendrimers

Biopolymers
Glòria SanclimensFernando Albericio

Abstract

Second-generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro-rich building blocks was carried out by stepwise solid-phase synthesis and their iterative addition was performed by a convergent approach, also using solid-phase synthesis. cis-4-Amino-L-proline and imidazolidine-2-carboxylic acid were used as branching units due to their structural resemblance to proline. The optimized strategy allowed the target compounds to be obtained with high purities without the need for purification steps.

References

Jan 1, 1982·International Journal of Peptide and Protein Research·N Helbecque, M H Loucheux-Lefebvre
Jan 15, 1994·The Biochemical Journal·M P Williamson
Jan 5, 2000·Biopolymers·S Sakakibara
Aug 29, 2000·The Journal of Peptide Research : Official Journal of the American Peptide Society·C CarreñoF Albericio
Jan 9, 2001·Trends in Cell Biology·M R Holt, A Koffer
Jun 20, 2002·Journal of Biotechnology·Kristen Sadler, James P Tam
Jul 26, 2002·Journal of the American Chemical Society·Laia CrespoErnest Giralt
Nov 27, 2002·Biochemistry·Kristen SadlerJames P Tam
Dec 19, 2002·Journal of the American Chemical Society·Garth A KinbergerMurray Goodman
Jun 25, 2004·Journal of Peptide Science : an Official Publication of the European Peptide Society·Pavel VeprekRashika El Ridi

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Citations

Aug 26, 2011·Bioconjugate Chemistry·Angela TorresMiriam Royo
May 30, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriel FischerCarmen Wängler
Mar 7, 2008·Bioorganic & Medicinal Chemistry Letters·Josep Farrera-SinfreuMiriam Royo
Jan 12, 2008·Advanced Drug Delivery Reviews·Sílvia Pujals, Ernest Giralt
Nov 22, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Petr NiederhafnerJan Jezek
Oct 1, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Petr NiederhafnerJan Jezek
Feb 6, 2017·Bioorganic & Medicinal Chemistry Letters·Lara PesChing-Hsuan Tung
May 12, 2005·Chemical Reviews·Laia CrespoFernando Albericio
Jul 18, 2017·Accounts of Chemical Research·Macarena Sánchez-NavarroErnest Giralt
Jul 30, 2005·The Journal of Organic Chemistry·Gloria SanclimensMiriam Royo

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