Solid-state characterization of paclitaxel

Journal of Pharmaceutical Sciences
R T LigginsH M Burt

Abstract

The purpose of this work was to characterize the solid-state properties of anhydrous paclitaxel and paclitaxel dihydrate. Paclitaxel I (anhydrous) was suspended in water for 24 h to convert it to paclitaxel.2H2O. Both forms were analyzed by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). X-ray powder diffraction (XRPD) patterns were obtained at 25, 100, and 195 degrees C. Dissolution profiles of both forms were obtained in water at 37 degrees C over h. DSC of paclitaxel.2H2O showed two endothermic peaks below 100 degrees C, corresponding to dehydration. The resulting solid phase was termed "dehydrated paclitaxel.2H2O". At 168 degrees C, a solid-solid transition was observed in which dehydrated paclitaxel.2H2O was converted to a semicrystalline material called "paclitaxel I/am". The solid-solid transition was followed by melting at 220 degrees C. TGA of paclitaxel.2H2O showed a corresponding biphasic weight loss below 100 degrees C, which was equivalent to the weight of 2 mol of water. DSC of paclitaxel I showed no transitions before melting at 220 degrees C, and no weight loss was observed by TGA. Quenching of paclitaxel I from the melt produced amorphous paclitaxel with a glass transition at 152 d...Continue Reading

References

Oct 1, 1991·Pharmacology & Therapeutics·D G Kingston
Sep 1, 1991·Pharmaceutical Research·A K Dash, R Suryanayanan
Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D MastropaoloN Camerman
Oct 1, 1995·Journal of Pharmaceutical Sciences·U S SharmaR M Straubinger
Aug 1, 1963·Journal of Pharmaceutical Sciences·E SHEFTER, T HIGUCHI

❮ Previous
Next ❯

Citations

Dec 8, 2005·Cancer Chemotherapy and Pharmacology·Jubo LiuChristine Allen
Apr 20, 2005·Pharmaceutical Research·Julie A StraubHoward Bernstein
May 6, 2009·Pharmaceutical Research·Nashwa El-Gendy, Cory Berkland
May 28, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Samantha A MeenachHeidi M Mansour
May 8, 2004·International Journal of Pharmaceutics·Ruiwen Shi, Helen M Burt
May 10, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sang Cheon LeeSeo Young Jeong
May 17, 2003·European Journal of Medicinal Chemistry·Arturo BattagliaAntonella Riva
Oct 19, 2013·Bioconjugate Chemistry·Simona MuraPatrick Couvreur
Jun 3, 2011·Molecular Pharmaceutics·Ho-Chul ShinGlen S Kwon
May 18, 2012·Molecular Pharmaceutics·Filippo RossiGiuseppe Perale
Jun 12, 2012·Molecular Pharmaceutics·Yingchao HanAlexander V Kabanov
Nov 28, 2008·Molecular Pharmaceutics·Peisheng XuYoon Yeo
Mar 8, 2008·Journal of Biomaterials Science. Polymer Edition·Beom-Young RyuByung-Wook Jo
Mar 12, 2005·The AAPS Journal·Anand Babu Dhanikula, Ramesh Panchagnula
May 31, 2012·AAPS PharmSciTech·Zerrin Sezgin-Bayindir, Nilufer Yuksel
Jan 24, 2008·PloS One·Margit FossDahong Zhang
Jan 7, 2014·PloS One·Anne SeidlitzWerner Weitschies
Feb 7, 2014·Pakistan Journal of Biological Sciences : PJBS·M ZareiA Akbarzadeh
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael ChornyRobert J Levy
Feb 3, 2016·Colloids and Surfaces. B, Biointerfaces·Josimar O EloyJuliana Maldonado Marchetti
Feb 22, 2012·Drug Development and Industrial Pharmacy·Amit K ShahSteven P Stodghill
Jun 24, 2008·Endothelium : Journal of Endothelial Cell Research·H GallagherY Rochev
Nov 7, 2003·Journal of Pharmaceutical Sciences·Neslihan GursoySimon Benita
Sep 3, 2010·Journal of Pharmaceutical Sciences·Sukhdeep KenthJean-Christophe Leroux
Sep 26, 2009·Journal of Pharmaceutical Sciences·Zerrin Sezgin Bayindir, Nilufer Yuksel
Jan 3, 2013·Journal of Pharmaceutical Sciences·Yiyi YuXiangrong Song
Dec 18, 2001·Journal of Pharmaceutical Sciences·M A LovichE R Edelman
Dec 4, 2012·Journal of Pharmaceutical Sciences·Liana Vella-ZarbRobert E Dinnebier
Oct 23, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Johannes MoesBastiaan Nuijen
Jun 27, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brian E KilfoyleBozena B Michniak-Kohn
May 26, 2011·International Journal of Pharmaceutics·Michael C CochranMargaret A Wheatley
May 18, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kanwaldeep K GillAmal Kaddoumi
Feb 22, 2011·The Journal of Urology·Ze LuJessie L-S Au

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.