PMID: 11906261Mar 22, 2002Paper

Solid-state NMR investigation of indomethacin-cyclodextrin complexes in PEG 6000 carrier

Bioconjugate Chemistry
M WulffJörgen Tegenfeldt

Abstract

Various solid dispersions of alpha-, beta- and gamma-cyclodextrin (CD) in PEG 6000 with and without the addition of 5% w/w indomethacin were prepared by the melting method using the original components. The samples were investigated by solid-state (13)C NMR, and the interactions between the drug and the cyclodextrins were evaluated. The indomethacin-gamma-CD phase with tetragonal symmetry found in a previous X-ray study gave chemical shifts which suggested that this phase is a complex between indomethacin and gamma-CD. Evidence of an indomethacin-beta-CD complex were found. A distribution of the chemical shifts for beta-CD was attributed to the possible formation of different types of complexes between indomethacin and beta-CD. No complex formation was found in the alpha-CD system. The degree of relative crystallinity of the samples in the gamma-CD system was measured by (1)H NMR, X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), and modulated-temperature DSC (MTDSC). The results obtained by the NMR, XRD, and DSC techniques showed that the dispersions were less crystalline than the pure polymer carrier, and the dispersion containing the indomethacin-gamma-CD complex had the lowest degree of crystallinity....Continue Reading

References

Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Jul 30, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Wulff, M Aldén
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Leuner, J Dressman
Jun 1, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G PielL Delattre

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Citations

Jul 30, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Wulff, M Aldén
Jan 9, 2014·Solid State Nuclear Magnetic Resonance·Ewa SkorupskaMarek J Potrzebowski
Jul 7, 2005·Organic & Biomolecular Chemistry·Yu LiuJing Chen
Dec 17, 2009·Journal of Pharmaceutical Sciences·Jean-Baptiste GuilbaudYaroslav Z Khimyak
Jan 30, 2010·Journal of Pharmaceutical Sciences·Jean-Baptiste GuilbaudYaroslav Z Khimyak
Apr 7, 2015·Carbohydrate Polymers·M João G FerreiraTeresa G Nunes
Jan 13, 2015·International Journal of Pharmaceutics·Shashi Ravi Suman RudrangiStephen Richard Wicks
Sep 27, 2012·Molecular Pharmaceutics·Frederick G Vogt, Mark Strohmeier
Aug 26, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Banibrata MaityDebabrata Seth
Mar 2, 2017·Advanced Materials·Alessandro MarchettiXueqian Kong
May 24, 2020·International Journal of Pharmaceutics·Xue LiRuxandra Gref
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marianna PorcinoCharlotte Martineau-Corcos
Feb 14, 2006·The Journal of Physical Chemistry. B·L CarpentierM Descamps

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