Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

Annals of Biomedical Engineering
Maria KalliTriantafyllos Stylianopoulos

Abstract

Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated fibroblasts can acquire an activated phenotype and produce excessive amounts of extracellular matrix creating a highly dense stroma, a situation known as desmoplasia. Desmoplasia, along with the uncontrolled proliferation of cancer cells, leads to the development of compressive forces within the tumor, generating the so-called solid stress. Solid stress is previously shown to affect cancer cell proliferation and migration, however there is no pertinent study taking into account the effects of solid stress on fibroblasts and whether these effects contribute to tumor progression. In this work, we applied a defined compressive stress on pancreatic fibroblasts, similar in magnitude to that experienced by cells in native pancreatic tumors. Our results suggest that solid stress stimulates fibroblasts activation and strongly upregulates Growth Differentiation Factor-15 (GDF15) expression. Moreover, co-culture of compression-induced activated fibroblasts with pancreatic cancer cells significantly promotes cancer cell migr...Continue Reading

References

Aug 1, 1997·Nature Biotechnology·G HelmlingerR K Jain
Apr 16, 2002·British Journal of Cancer·C KoikeR K Jain
Mar 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·John B WelshGarret M Hampton
Nov 19, 2004·Nature·Neil A BhowmickHarold L Moses
Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A BrownSamuel N Breit
Apr 5, 2007·Molecular Cancer Therapeutics·Daruka Mahadevan, Daniel D Von Hoff
Feb 5, 2008·Cancer Research·Rosa F HwangCraig D Logsdon
Oct 3, 2008·Cancer Research·Alain VonlaufenMinoti V Apte
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Sophie ShnaperMonika E Hegi
Jun 26, 2010·Journal of Cellular Physiology·Murielle Mimeault, Surinder K Batra
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sukhvinder S SidhuJohn V Fahy
Sep 9, 2010·Current Opinion in Cell Biology·Mikala EgebladValerie M Weaver
Nov 18, 2010·Biochemical and Biophysical Research Communications·Kazuhiro KikutaTooru Shimosegawa
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Janet M TseLance L Munn
Aug 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Triantafyllos StylianopoulosRakesh K Jain
Oct 2, 2012·Molecular Cancer Research : MCR·George S KaragiannisEleftherios P Diamandis
Sep 3, 2013·Journal of Cellular Physiology·Koh Meng Aw YongRobert H Getzenberg
May 2, 2014·Cancer Research·Francesca BruzzeseMartin Augsten
Jul 12, 2014·Annual Review of Biomedical Engineering·Rakesh K JainTriantafyllos Stylianopoulos
Nov 25, 2014·Biophysical Journal·Morgan DelarueGiovanni Cappello
Jan 13, 2015·International Journal of Oncology·Panagiotis Papageorgis, Triantafyllos Stylianopoulos
May 30, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qingfeng HuGuowei Xia
Oct 27, 2015·Oncotarget·Chen LiMaode Lai
Mar 19, 2016·Journal of Cellular and Molecular Medicine·Chen LiHonghe Zhang
Aug 24, 2016·Nature Reviews. Cancer·Raghu Kalluri
Nov 26, 2016·Neoplasia : an International Journal for Oncology Research·Chrysovalantis VoutouriTriantafyllos Stylianopoulos
Dec 3, 2016·Nature Reviews. Cancer·Colin D PaulKonstantinos Konstantopoulos
Dec 14, 2016·World Journal of Gastroenterology : WJG·Milena Ilic, Irena Ilic
Jun 2, 2017·Alimentary Pharmacology & Therapeutics·M DantaD A Brown
Sep 12, 2017·The Journal of Clinical Investigation·Nivedita M RatnamDenis C Guttridge
Jan 1, 2016·Nature Biomedical Engineering·Hadi T NiaRakesh K Jain

❮ Previous
Next ❯

Citations

May 23, 2019·Journal of the Royal Society, Interface·Andreas StylianouTriantafyllos Stylianopoulos
Apr 17, 2020·Physiological Reviews·Elisabeth HessmannAlbrecht Neesse
Mar 30, 2018·Frontiers in Oncology·Maria Kalli, Triantafyllos Stylianopoulos
May 22, 2020·Journal of Translational Medicine·Anette Hauge, Einar K Rofstad
Jan 10, 2019·International Journal of Molecular Sciences·Vasiliki GkretsiTriantafyllos Stylianopoulos
May 30, 2019·Cancers·Pietro MascheroniHaralampos Hatzikirou
Nov 27, 2019·Annals of Biomedical Engineering·Bethany Rowson
Nov 27, 2019·Annals of Biomedical Engineering·Bethany Rowson, Stefan M Duma
May 22, 2018·Frontiers in Oncology·Vasiliki Gkretsi, Triantafyllos Stylianopoulos
May 30, 2019·Cancers·Imjoo Jang, Karen A Beningo
Oct 6, 2020·Physical Review Letters·Ilaria Francesca RizzutiMorgan Delarue
Nov 22, 2020·Annals of Biomedical Engineering·Bethany Rowson
Oct 2, 2020·Cancers·Fabian Bernhard Pallasch, Udo Schumacher
Dec 21, 2018·Emerging Topics in Life Sciences·Alain VellaArmando Del Río Hernández
Mar 6, 2021·Cancer Cell International·Se Jik HanKyung Sook Kim
May 8, 2019·Developmental Cell·FuiBoon KaiValerie M Weaver
Aug 23, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Matthew HaddenYogambha Ramaswamy
Jun 10, 2021·Developmental Cell·Mary-Kate HaywardValerie M Weaver
Jun 5, 2021·Journal of Theoretical Biology·Jahn Otto WaldelandSteinar Evje

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
immunoprecipitation assay
protein assay
Transfection
Enzyme-linked immunosorbent assay
ELISA

Software Mentioned

ImageJ

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.