Abstract
The objective of this study is to evaluate requirements for radionuclide-based solid tumor therapy by assessing the radial dose distribution of beta-particle-emitting and alpha-particle-emitting molecules localized either solely within endothelial cells of tumor vasculature or diffusing from the vasculature throughout the adjacent viable tumor cells. Tumor blood vessels were modeled as a group of microcylindrical layers comprising endothelial cells (one-cell thick, 10 microm diameter), viable tumor cells (25-cell thick, 250 microm radius), and necrotic tumor region (> 250 microm from any blood vessel). Sources of radioactivity were assumed to distribute uniformly in either endothelial cells or in concentric cylindrical 10 microm shells within the viable tumor-cell region. The EGSnrc Monte Carlo simulation code system was used for beta particle dosimetry and a dose-point kernel method for alpha particle dosimetry. The radioactive decays required to deposit cytocidal doses (> or = 100 Gy) in the vascular endothelial cells (endothelial cell mean dose) or, alternatively, at the tumor edge [tumor-edge mean dose (TEMD)] of adjacent viable tumor cells were then determined for six beta (32P, 33P, 67Cu, 90Y 131I, and 1188Re) and two alp...Continue Reading
References
Jan 1, 1989·Microvascular Research·L T Baxter, R K Jain
Jan 1, 1989·Medical Physics·R W HowellK S Sastry
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Sep 1, 1984·Medical Physics·B W Wessels, R D Rogus
Jan 1, 1993·Acta Oncologica·S E StrandJ Tennvall
Feb 1, 1994·Cancer·D R Fisher
Mar 1, 1993·Medical Physics·P K Leichner, C S Kwok
Jan 1, 1996·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·J L Humm
Jul 2, 1999·British Journal of Cancer·S J KennelS Mirzadeh
Jan 12, 2000·Archives of Disease in Childhood·D Hall
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 23, 2000·Seminars in Radiation Oncology·D R Fisher
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Nov 10, 2001·Annual Review of Biomedical Engineering·R K Jain
Jun 20, 2002·Journal of the National Cancer Institute·Lynn HlatkyJudah Folkman
Jun 28, 2002·Cancer Cell·Judah Folkman
Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·Gamal AkabaniMichael R Zalutsky
Mar 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jörgen CarlssonJan Tennvall
Jan 22, 2005·Radiation Research·Roger W Howell, Prasad V S V Neti
Feb 22, 2005·Medical Physics·Ande BaoJames M Hevezi
Nov 22, 2005·Expert Opinion on Drug Delivery·Amin I Kassis
Feb 8, 2006·Radiation Protection Dosimetry·A WambersieH Paretzke
Jun 15, 2007·Microvascular Research·Dai Fukumura, Rakesh K Jain
Jan 17, 2008·Medical Physics·Indrin J ChettyJeffrey V Siebers
Citations
Mar 22, 2014·PloS One·Min ZhangBiao Li
Mar 15, 2011·Immunotherapy·Robert M Sharkey, David M Goldenberg
Mar 3, 2012·Medical Physics·Chen-Yu HuangBarry J Allen
Feb 8, 2013·Medical Physics·Piotr ZygmanskiErno Sajo
Jun 25, 2013·International Journal of Radiation Oncology, Biology, Physics·Helen HeyerdahlJostein Dahle
Dec 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Ross I BerbecoG Mike Makrigiorgos
Feb 8, 2014·Dermatologic Therapy·Daojin YanJing Wang
Sep 19, 2012·Computational and Mathematical Methods in Medicine·Chen-Yu HuangBarry J Allen
May 17, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Ernesto AmatoSergio Baldari
Mar 18, 2017·Radiation Oncology·Andrew B SatterleeLeaf Huang
Jan 19, 2018·Annual Review of Biomedical Engineering·Michael R McDevittStavroula Sofou
Oct 21, 2010·Physics in Medicine and Biology·Wilfred NgwaRoss I Berbeco
Aug 16, 2018·Stem Cell Research & Therapy·Lijian ShaoHuihong Zeng
Nov 18, 2015·Oncology Reports·Shuo ShiBiao Li
Nov 8, 2017·Oncology Letters·Jiahe ZhouConghui Han
Jun 20, 2020·Cancer Biotherapy & Radiopharmaceuticals·Francisco D C Guerra LiberalKevin M Prise
Apr 4, 2017·Biomaterials·Charles ZhuStavroula Sofou
Mar 23, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo Zanotti-Fregonara, Elif Hindié
Sep 6, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francis G BlankenbergJoseph M Backer