PMID: 12779350Jun 5, 2003Paper

Solid tumor therapy: manipulation of the vasculature with TNF

Technology in Cancer Research & Treatment
Timo L M ten Hagen, Alexander M M Eggermont

Abstract

Drug delivery to solid tumors is one of the most challenging aspects in cancer therapy. Whereas agents seem promising in the test tube, clinical trials often fail due to unfavorable pharmacokinetics, poor delivery, low local concentrations, and limited accumulation in the target cell. A major step forwards in the treatment of solid tumors is the recognition of the tumor-associated vasculature as an important target for therapy. Inhibition of tumor vascular development has a direct effect on the growth and progression of the tumor. Destruction of an existing vasculature also directly inflicts serious damage to the tumor cell. Moreover, the tumor vascular bed can be manipulated facilitating enhanced permissiveness of the tumor for administered chemotherapeutics. In this review, we focus on the use of tumor necrosis factor alpha (TNF) in local and systemic therapy in conjunction with chemotherapy. In these settings TNF demonstrates potent and selective activity on the tumor vascular bed, which strongly improves tumor response.

References

May 1, 1977·Annals of Surgery·E T KrementzI Hutton
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Dec 11, 1975·American Journal of Surgery·J S StehlinR F Anderson
Nov 1, 1992·World Journal of Surgery·G OmlorG Feifel
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D LienardF J Lejeune
Dec 15, 1990·International Journal of Cancer. Journal International Du Cancer·S SuzukiY Hashimoto
Jan 1, 1988·Immunopharmacology and Immunotoxicology·N WatanabeI Urushizaki
Apr 19, 1989·Journal of the National Cancer Institute·R K Jain
Nov 15, 1986·International Journal of Cancer. Journal International Du Cancer·P G BrouckaertW Fiers
Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Oct 1, 1982·European Journal of Cancer & Clinical Oncology·J WieberdinkG A Olthuis
Jul 1, 1995·The Journal of Pathology·N RenardD J Ruiter
Jul 1, 1994·Trends in Pharmacological Sciences·T M Allen
Jul 1, 1994·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·E KedarY Barenholz
Mar 1, 1994·Oncology·U Hieber, M E Heim
Jan 1, 1993·Pharmacology & Therapeutics·R S Sidhu, A P Bollon
Aug 1, 1993·The British Journal of Surgery·S HillJ M Thomas
Sep 1, 1993·The British Journal of Surgery·J M KlaaseH R Franklin
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F J LejeuneR O Mirimanoff
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M EggermontF J Lejeune
Jan 1, 1997·British Journal of Cancer·I H Borel RinkesA M Eggermont
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H R AlexanderS A Rosenberg
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D W NorthfeltD H Henry
Jul 22, 1998·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·M R de VriesA M Eggermont
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·A H van der VeenT L ten Hagen
Apr 28, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P LindnérP Naredi

❮ Previous
Next ❯

Citations

Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Katarzyna Krukiewicz, Jerzy K Zak
Dec 18, 2008·Cancer·Anita TandleSteven K Libutti
Nov 3, 2005·Biochimica Et Biophysica Acta·Curzio RüeggGian Carlo Alghisi
Feb 27, 2018·Journal of the National Cancer Institute·Naris NilubolElectron Kebebew
Mar 28, 2008·Immunological Reviews·Timo L M ten HagenAlexander M M Eggermont
Jun 29, 2004·Journal of Translational Medicine·Anita TandleSteven K Libutti
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven K LibuttiLawrence Tamarkin
Apr 15, 2021·Biomedical Materials·S Ram PrasadA Jayakrishnan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.