Solitary dermal melanoma: beginning or end of the metastatic process?

Annals of Surgical Oncology
Chris C LeeDonald L Morton

Abstract

Solitary dermal melanoma (SDM) is confined to the dermal and/or subcutaneous tissue without an epidermal component. It is unclear whether this lesion is a subtype of primary melanoma or distant cutaneous metastasis from an unknown primary. We evaluated our large experience to determine the prognosis and optimal management of SDM. Our melanoma referral center's database of prospectively acquired records was used for identification and clinicopathologic analysis of patients presenting with SDM between 1971 and 2005. Of 12,817 database patients seen during a 34-year period, 101 (0.8%) had SDM. Of 92 patients free of distant metastasis on initial presentation, 55 (60%) were observed and 37 (40%) underwent surgical nodal staging: regional metastases were identified in 7 (19%). Nodal recurrence occurred in 1 of 30 patients (3.3%) with histopathology-negative nodes compared with 13 of 55 patients (24%) who underwent nodal observation instead of nodal staging. Thus, 21 of 92 patients (23%) had nodal metastasis identified during surgical nodal staging or postoperative nodal observation. At a median follow-up of 68 months, estimated 5-year overall survival rate was 73% for 71 patients with localized disease versus 67% for 21 patients wit...Continue Reading

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Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chris C LeeDonald L Morton

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Citations

Mar 13, 2014·Actas dermo-sifiliográficas·E Piqué-Duran
Mar 19, 2014·Actas dermo-sifiliográficas·M González de Arriba
Jan 22, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Wei-Chen Chen, Yuan-Yu Hsueh
May 27, 2015·Cancers·Vidhya R RaoSaverio Gentile
Feb 26, 2015·Journal of Surgical Oncology·Yinin HuCraig L Slingluff
Dec 15, 2015·Journal of Surgical Oncology·Matthew P DoepkerJonathan S Zager
May 13, 2015·ANZ Journal of Surgery·James TeowBenjamin A Wood
Aug 13, 2015·Cancers·Elke J A H van BeekW Martin C Klop
Dec 15, 2017·The American Journal of Surgical Pathology·Lucie CellierArnaud de la Fouchardière
Nov 28, 2018·Journal of Surgical Oncology·Yun Song, Giorgos C Karakousis
Sep 12, 2020·Journal of Cutaneous Medicine and Surgery·Hadas ZamirHaim Gutman
Feb 5, 2021·Dermatopathology·Oriana SimonettiAnnamaria Offidani

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