Abstract
We herein report the clinical, radiological, and pathological findings of a rare case of a solitary fibrous tumor (SFT) occurring in the breast parenchyma of a 62-year-old female. The tumor was incidentally detected at a mammographic screening, and, ultrasonographically, presented as a single, well-circumscribed nodule. On needle core biopsy, the diagnosis of SFT was suggested based on a proliferation of CD34-positive spindly cells set in a fibrous stroma containing medium-sized blood vessels with hyalinization of their walls and branching configuration. The diagnosis was confirmed in the excised specimen, which exhibited a tumor with an immunohistochemical profile consistent with SFT, including diffuse expression of CD34, CD99 and bcl2. As STAT6 nuclear immunoexpression is the result of the inv12(q13q13)-derived NAB2-STAT6 fusion, which characterizes SFT, we analyzed immunohistochemically our case with a commercially available anti-STAT6 antibody. We showed that mammary SFT exhibits a diffuse nuclear STAT6 immunoreactivty, suggesting its potential diagnostic role. The present case emphasizes that the diagnosis of SFT can be confidentially rendered on needle core biopsy. Although SFT is suspected on characteristic morphologic f...Continue Reading
References
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·S DamianiV Eusebi
Aug 1, 1997·Southern Medical Journal·M A KhalifaE E Lack
Nov 14, 1997·Histopathology·P Dal CinH Van den Berghe
Feb 3, 1998·Histopathology·J K Chan
Dec 16, 1998·The American Journal of Surgical Pathology·A V Vallat-DecouvelaereC D Fletcher
Jun 26, 1999·Histopathology·A Al-Nafussi
Jul 6, 2000·The Journal of Pathology·P PauwelsP Dal Cin
Aug 3, 2001·Pathology, Research and Practice·G MagroM Bisceglia
May 20, 2003·The Breast Journal·Alessandro BombonatiJuan P Palazzo
Apr 13, 2004·Seminars in Diagnostic Pathology·Edi Brogi
Jun 9, 2004·Annals of Diagnostic Pathology·Giovanni FalconieriStefano Pizzolitto
May 23, 2006·Virchows Archiv : an International Journal of Pathology·Francesca MaggianiRaf Sciot
Aug 31, 2007·Histopathology·F MaggianiR Sciot
Feb 8, 2008·World Journal of Surgical Oncology·Francesca RoveraRenzo Dionigi
Apr 4, 2008·The Breast Journal·Ari-Nareg MeguerditchianSwati Kulkarni
Jan 10, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gaetano MagroPaolo Greco
Sep 21, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Uta FluckeThomas Mentzel
Mar 5, 2011·Pathology, Research and Practice·Giada Maria VecchioGaetano Magro
May 12, 2012·Human Pathology·Gaetano MagroMichal Michal
Jan 15, 2013·Nature Genetics·Dan R RobinsonArul M Chinnaiyan
Jan 15, 2013·Nature Genetics·Juliann ChmieleckiMatthew Meyerson
Mar 15, 2014·The American Journal of Surgical Pathology·Akihiko YoshidaRyoji Kushima
Mar 19, 2014·Pathology, Research and Practice·Anne-Laure TrépantJean-Christophe Noël
Jun 2, 2014·Human Pathology·Gaetano MagroMichal Michal
Dec 20, 2014·Human Pathology·Gaetano Magro
Aug 1, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hui-Chun TaiHsuan-Ying Huang
Citations
Mar 20, 2018·International Journal of Surgical Pathology·Christopher J SchwartzFarbod Darvishian
Nov 22, 2019·Pathologica·G M VecchioG Magro
Aug 27, 2019·Clinical Pathology·Israel BarcoAntonio García-Fernández
Jun 18, 2017·The Breast Journal·Nikolaos S Salemis
Jan 5, 2021·Pathologica·Giuseppe BroggiGaetano Magro
Jan 5, 2021·Pathologica·Gaetano MagroSergio Castorina