Solitary fibrous tumor of the meninges. Case report and review of the literature

Journal of Neurosurgery
Richard A PraysonGene H Barnett

Abstract

The authors present the case of a left frontal solitary fibrous tumor of the meninges. The gross appearance of the tumor was very similar to that of a fibroblastic meningioma. Histological examination showed a mixture of spindle-shaped and round cells arranged in a collagen matrix. Immunohistochemical staining of the tumor demonstrated diffuse positive staining for CD34 and vimentin. The tumor displayed no positive staining for markers of muscle, epithelial, glial, or neurocrest differentiation or for estrogen and progesterone receptors. The MIB-1 labeling index (the percentage of positive staining tumor cell nuclei), a marker of cellular proliferation, was 1.1%. Ultrastructural studies support attributing a mesenchymal, rather than meningothelial, nature to the tumor. A differential diagnosis is discussed and a review of the literature on these rare tumors is presented.

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Citations

Aug 24, 2001·Brain Tumor Pathology·N SannoA Teramoto
Jun 16, 1999·Surgical Neurology·A BrunoriF Chiappetta
Dec 16, 1998·The American Journal of Surgical Pathology·A V Vallat-DecouvelaereC D Fletcher
Jan 7, 2004·The American Journal of Surgical Pathology·Fausto RodriguezCaterina Giannini
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Sep 2, 2000·Journal of Neurosurgery·H K NgW S Poon
Nov 27, 2002·Journal of Neurosurgery·Naoki ShinojimaYukitaka Ushio
Dec 16, 2004·Journal of Neurosurgery·Katsuyoshi MiyashitaJunkoh Yamashita
Nov 24, 2006·Journal of Neurosurgery·Kuniaki NakaharaKiyotaka Fujii
Feb 9, 2010·Neurology India·Rabi Narayan SahuV K Jain
Mar 4, 2014·Ultrastructural Pathology·Tomu OkadaSaburou Yagishita
Jan 7, 2003·Human Pathology·Mahlon D JohnsonPaul L Moots
Sep 17, 2002·International Journal of Surgical Pathology·Elias A CastillaGene H Barnett
Sep 1, 2011·International Journal of Surgical Pathology·Michele BiscegliaGaetano Magro
Aug 19, 2004·Neurosurgery·Mitsuhiro KawamuraHiroshi Hirano
May 25, 2005·The Kaohsiung Journal of Medical Sciences·Shih-Wen HuChee-Yin Chai
Feb 28, 2001·Neurosurgery·I F PollackC H Snyderman
May 28, 2005·Neurosurgery·Rebecca Gillian MacfarlaneDavid Glyndor Treharne Thomas
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Aug 15, 2014·Oncology Letters·Qingsheng XuYongqing Zhou
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Mar 17, 2000·Neurosurgery·J VaqueroM Pedrosa
Sep 20, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kerem BikmazCem A Gokduman

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BETA
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