Solitary fibrous tumour of the kidney with sarcomatous overgrowth. Case report and review of the literature

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Gaetano MagroPaolo Greco

Abstract

Solitary fibrous tumour (SFT) rarely occurs in the kidney, with only one case exhibiting malignant behaviour. We report the case of a typical SFT of the kidney with sarcomatous overgrowth in a 34-year-old woman. This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34+ mitotically active atypical plump spindle- to epithelioid-shaped cells, including pleomorphic multinucleated giant cells. A novel immunohistochemical finding was diffuse and strong S-100 protein expression by sarcomatous cells. This should be kept in mind by pathologists to avoid confusion with other S-100 protein-positive malignant neoplasms.

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Citations

Jun 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S StacchiottiP G Casali
Mar 8, 2013·Case Reports in Nephrology and Urology·Hideo SasakiTatsuya Chikaraishi
Oct 6, 2011·Diagnostic Pathology·Tsan-Yu HsiehJim-Ray Chen
May 11, 2013·Case Reports in Urology·Abdullah DemirtaşDeniz Demirci
Feb 13, 2013·Case Reports in Oncological Medicine·Javier Cuello, Ricardo Brugés
Mar 19, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Alampady K ShanbhogueKumaresan Sandrasegaran
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Jan 27, 2015·Oncology Letters·Wang Shi, Zheng Wei
Jun 1, 2018·Archives of Pathology & Laboratory Medicine·Nicholas J Olson, Konstantinos Linos
Aug 28, 2019·The Journal of International Medical Research·Shuangjian JiangJunxing Chen
May 23, 2012·The American Journal of Surgical Pathology·Paola ColliniSilvana Pilotti
May 3, 2011·International Journal of Surgical Pathology·Giulia VitaMichele Bisceglia
Sep 3, 2016·Clinical Sarcoma Research·Vittoria ColiaSilvia Stacchiotti
Jul 3, 2013·International Journal of Surgical Pathology·William W WuLisa Shane
Apr 19, 2011·Acta Radiologica·Neeraj LalwaniCarlos Restrepo
Aug 27, 2019·Clinical Pathology·Israel BarcoAntonio García-Fernández
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Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S StacchiottiP G Casali

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